CBR3 Antibody

1. CBR3 730G>A is significantly associated with recurrence- free survival in patients who received intravesical chemotherapy with pirarubicin after complete transurethral resection. PMID: 30125887
2. No significant correlation between cardiotoxicity and SNPs within the CBR pathway. Further investigation into CBR SNPs in a larger adult sample is needed. PMID: 26563179
3. association of SNPs in ABCB1 and CBR3 with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines. PMID: 26799497
4. Variants of CBR3 and GSTP1 enzymes may be associated with changes in short-term functional cardiac parameters. PMID: 23182048
5. genetic polymorphism in the CBR3 gene conferred risk of type 2 diabetes and insulin resistance in Chinese. The association was probably mediated through modulation of adipogenesis. PMID: 22527884
6. CBR3 polymorphisms contribute to increased cardiomyopathy risk associated with anthracycline treatment of childhood cancer. PMID: 22124095
7. CBR3 is a novel target gene of inflammatory stimuli; elucidation of its detailed role in inflammation deserves further investigation. PMID: 22425771
8. Computational searches identify a conserved antioxidant response element(ARE) in the distal carbonyl reductase 3 (CBR3) promoter region. PMID: 22001310
9. The CBR3 distal promoter contains an activating cis-regulatory element that is responsive to Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
10. CBR3 is regulated via NRF2-dependent signaling pathways, a finding and plays an important role in the cellular response to oxidative stress. PMID: 20806931
11. analysis of the structural basis for substrate specificity in human monomeric carbonyl reductases CBR3 PMID: 19841672
12. The common carbonyl reductase 3 (CBR3)valine244methionine polymorphism encodes for CBR3 isoforms with distinctive enzymatic properties, as revealed in DNA variation panels from 10 ethnic groups. PMID: 15537833
13. There was a trend toward an association between the CBR3 V244M polymorphism and the risk of CHf PMID: 18457324
14. Polymorphisms in CBR3 may explain interindividual and interethnic variability of doxorubicin pharmacokinetics and pharmacodynamics. PMID: 18551042
15. CBR3 polymorphisms have no significant influence on the pharmacokinetics of doxorubicin in Asian breast cancer patients. PMID: 19016765
16. identified the promoter of human CBR3. Liver samples from black donors showed higher relative CBR3 mRNA levels than samples from whites PMID: 19590938
17. carbonyl reductase has an important function in modifying the metastatic behavior of malignant tumors. PMID: 10728668
18. Decreased Carbonyl Reductase expression in epithelial ovarian cancer is associated with RLN metastasis and poor survival PMID: 11592776

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HGNC: 1549

OMIM: 603608

KEGG: hsa:874

STRING: 9606.ENSP00000290354

UniGene: Hs.154510