CBX8 Antibody

1. CBX8 functions as an oncogene to upregulate EGR1 and miR-365-3p to stimulate the AKT/beta-catenin pathway in hepatocellular carcinoma.CBX8 expression is increased and associated with poor outcomes in hepatocellular carcinoma. PMID: 29066512
2. CBX8 binds with the Snai1 promoter, represses Snai1 transcription and suppresses esophageal carcinoma metastasis. PMID: 28912889
3. The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients. PMID: 28837252
4. CBX8 binds to H3K27me3 at bivalent promoters during germinal center formation, and recruits a novel PRC1-BCOR complex at BCL6 binding sites to specifically silence genes in the germinal center and promote lymphomagenesis PMID: 27505670
5. CBX8 plates roles in epigenetic regulation in DNA damage response. PMID: 27555324
6. IGF1 can promote the colon cancer cell line, HCT116 cell, proliferation via promoting Cbx8 expression PMID: 25398592
7. The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues. PMID: 26837964
8. These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment. PMID: 26718407
9. Low CBX8 expression was associated with distant metastasis in colorectal cancer. PMID: 25360999
10. CBX8 might emerge as an oncogene for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy. PMID: 25197352
11. The presence of CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics. PMID: 24460908
12. Interaction with CBX8 precludes AF9-DOT1L binding. PMID: 23891621
13. CBX8 cooperated with SIRT1 for suppressing p53 acetylation induced by Sirtinol and etoposide/TSA. Upon ectopic expression, CBX8 or SIRT1 repressed the expression of p21(WAF1) by inhibiting p53 binding to the promoter. PMID: 23474493
14. CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis. PMID: 22094252
15. CBX8 is an essential component of one of the polycomb repressive complexes, which directly regulate the expression of numerous target genes, including the INK4A-ARF locus, involved in cell-fate decisions. PMID: 17332741

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HGNC: 15962

OMIM: 617354

KEGG: hsa:57332

STRING: 9606.ENSP00000269385

UniGene: Hs.387258