CBX8 Antibody

Datasheet

Code	CSB-PA864026ESR2HU
Size	US$166
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Image	Western blot All lanes: CBX8 antibody at 2μg/ml + Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 43 kDa Observed band size: 43 kDa Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA864026ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA864026ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA864026ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CBX8 Polyclonal antibody

Uniprot No.

Q9HC52

Target Names

CBX8

Alternative Names

Cbx8 antibody; CBX8_HUMAN antibody; Chromobox Homolog 8 (Drosophila Pc Class) antibody; Chromobox Homolog 8 (Pc Class Homolog; Drosophila) antibody; Chromobox Homolog 8 antibody; Chromobox protein homolog 8 antibody; hPc3 antibody; Pc Class 3 Homolog (Drosophila) antibody; Pc Class 3 Homolog antibody; Pc3 antibody; Polycomb 3 antibody; Polycomb 3 homolog antibody; RC1 antibody; Rectachrome 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Chromobox protein homolog 8 protein (80-280AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene References into Functions

CBX8 functions as an oncogene to upregulate EGR1 and miR-365-3p to stimulate the AKT/beta-catenin pathway in hepatocellular carcinoma.CBX8 expression is increased and associated with poor outcomes in hepatocellular carcinoma. PMID: 29066512
CBX8 binds with the Snai1 promoter, represses Snai1 transcription and suppresses esophageal carcinoma metastasis. PMID: 28912889
The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients. PMID: 28837252
CBX8 binds to H3K27me3 at bivalent promoters during germinal center formation, and recruits a novel PRC1-BCOR complex at BCL6 binding sites to specifically silence genes in the germinal center and promote lymphomagenesis PMID: 27505670
CBX8 plates roles in epigenetic regulation in DNA damage response. PMID: 27555324
IGF1 can promote the colon cancer cell line, HCT116 cell, proliferation via promoting Cbx8 expression PMID: 25398592
The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues. PMID: 26837964
These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment. PMID: 26718407
Low CBX8 expression was associated with distant metastasis in colorectal cancer. PMID: 25360999
CBX8 might emerge as an oncogene for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy. PMID: 25197352
The presence of CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics. PMID: 24460908
Interaction with CBX8 precludes AF9-DOT1L binding. PMID: 23891621
CBX8 cooperated with SIRT1 for suppressing p53 acetylation induced by Sirtinol and etoposide/TSA. Upon ectopic expression, CBX8 or SIRT1 repressed the expression of p21(WAF1) by inhibiting p53 binding to the promoter. PMID: 23474493
CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis. PMID: 22094252
CBX8 is an essential component of one of the polycomb repressive complexes, which directly regulate the expression of numerous target genes, including the INK4A-ARF locus, involved in cell-fate decisions. PMID: 17332741

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Subcellular Location

Nucleus.

Database Links

HGNC: 15962

OMIM: 617354

KEGG: hsa:57332

STRING: 9606.ENSP00000269385

UniGene: Hs.387258

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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