CBY1 Antibody

1. FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling processes. PMID: 27528616
2. chronic Cby1 knockdown in colon cancer cells may counteract tumor progression by promoting the mesenchymal-to-epithelial transition process. PMID: 28107095
3. Cby's C-terminal domain alone binds to TC-1 with significantly greater affinity compared to full-length Cby, implying that target binding of the coiled-coil domain is affected by the flanking disordered regions. PMID: 27082063
4. CBY1 downregulation in CML comes from reduced protein stability when bound to 14-3-3sigma adapter protein. Dissociation raises CBY1 protein levels by enhancing its stability. The ubiquitin proteasome system reduces 14-3-3sigma-bound CBY1 stability by SUMOylation. PMID: 26147002
5. Study showed that expression of Cby protein was strongly downregulated in laryngeal squamous cell carcinoma (LSCC) tumor tissues in comparison to normal laryngeal mucosa samples. PMID: 25175341
6. the impact of BCR-ABL1 on Chibby1, a beta catenin antagonist involved in cell differentiation and transformation PMID: 24339928
7. Stable expression of CBY1 drives beta catenin cytoplasmatic translocation and impairs beta catenin signaling in BCR-ABL + cells. PMID: 23707389
8. Results from the association analysis suggest that common variation in CBY is not a cause for obesity in the Belgian population. PMID: 23645032
9. C-terminal polycystin-2 influences the interaction with PIGEA14 PMID: 23838289
10. Cby plays an important role in organization of both primary and motile cilia in collaboration with Cnx. PMID: 22911743
11. The N-terminal portion of the CBY1 is unstructured in solution, but the C-terminal half forms a coiled-coil structure. PMID: 21182262
12. Chibby and clusterin were co-immunoprecipitated with NBPF1. PMID: 20096688
13. These findings unravel the molecular basis through which a combinatorial action of Cby and 14-3-3 proteins controls the dynamic nuclear-cytoplasmic trafficking of beta-catenin. PMID: 19940019
14. Chibby inhibits beta-catenin-mediated transcriptional activation by competing with Lef-1 to bind to beta-catenin PMID: 12712206
15. PIGEA-14 plays an important role in regulating the intracellular location of polycystin-2 PMID: 15194699
16. As no somatic mutation was detected in C22orf2 in 36 colorectal tumour DNA, our results do not support the implication of Chibby as a tumour suppressor in colorectal carcinogenesis. PMID: 15245581
17. Chibby is not likely to promote colorectal carcinoma tumor development or progression. PMID: 16570344
18. CBY promotes adipocyte differentiation through inhibition of beta catenin signaling. PMID: 17403895
19. intrinsically disordered TC-1 interacts with Cby via its transient helical structure PMID: 17905836
20. 14-3-3epsilon and 14-3-3zeta are identified as Cby-binding partners. PMID: 18573912
21. genes including CHIBBY involved in pediatric ependymomas. PMID: 18663750
22. Alanine substitutions of two or more of four critical leucine residues within the C-terminal heptad repeats eliminate the Cby-Cby interaction. PMID: 19435523

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HGNC: 1307

OMIM: 607757

KEGG: hsa:25776

STRING: 9606.ENSP00000216029

UniGene: Hs.334911