CBY1 Antibody,FITC conjugated

Code CSB-PA896889LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CBY1 Polyclonal antibody
Uniprot No.
Target Names
CBY1
Alternative Names
ARPP-binding protein antibody; C22orf2 antibody; CBY antibody; Cby1 antibody; CBY1_HUMAN antibody; Cytosolic leucine rich protein antibody; Cytosolic leucine-rich protein antibody; Golgi and endoplasmic reticulum-associated 1 antibody; HRIHFB2025 antibody; PIGEA 14 antibody; PIGEA-14 antibody; PKD2 interactor antibody; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1 antibody; Protein Chibby antibody; Protein chibby homolog 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein chibby homolog 1 protein (41-126AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Antigen Affinity purified & Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
Gene References into Functions
  1. FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling processes. PMID: 27528616
  2. chronic Cby1 knockdown in colon cancer cells may counteract tumor progression by promoting the mesenchymal-to-epithelial transition process. PMID: 28107095
  3. Cby's C-terminal domain alone binds to TC-1 with significantly greater affinity compared to full-length Cby, implying that target binding of the coiled-coil domain is affected by the flanking disordered regions. PMID: 27082063
  4. CBY1 downregulation in CML comes from reduced protein stability when bound to 14-3-3sigma adapter protein. Dissociation raises CBY1 protein levels by enhancing its stability. The ubiquitin proteasome system reduces 14-3-3sigma-bound CBY1 stability by SUMOylation. PMID: 26147002
  5. Study showed that expression of Cby protein was strongly downregulated in laryngeal squamous cell carcinoma (LSCC) tumor tissues in comparison to normal laryngeal mucosa samples. PMID: 25175341
  6. the impact of BCR-ABL1 on Chibby1, a beta catenin antagonist involved in cell differentiation and transformation PMID: 24339928
  7. Stable expression of CBY1 drives beta catenin cytoplasmatic translocation and impairs beta catenin signaling in BCR-ABL + cells. PMID: 23707389
  8. Results from the association analysis suggest that common variation in CBY is not a cause for obesity in the Belgian population. PMID: 23645032
  9. C-terminal polycystin-2 influences the interaction with PIGEA14 PMID: 23838289
  10. Cby plays an important role in organization of both primary and motile cilia in collaboration with Cnx. PMID: 22911743
  11. The N-terminal portion of the CBY1 is unstructured in solution, but the C-terminal half forms a coiled-coil structure. PMID: 21182262
  12. Chibby and clusterin were co-immunoprecipitated with NBPF1. PMID: 20096688
  13. These findings unravel the molecular basis through which a combinatorial action of Cby and 14-3-3 proteins controls the dynamic nuclear-cytoplasmic trafficking of beta-catenin. PMID: 19940019
  14. Chibby inhibits beta-catenin-mediated transcriptional activation by competing with Lef-1 to bind to beta-catenin PMID: 12712206
  15. PIGEA-14 plays an important role in regulating the intracellular location of polycystin-2 PMID: 15194699
  16. As no somatic mutation was detected in C22orf2 in 36 colorectal tumour DNA, our results do not support the implication of Chibby as a tumour suppressor in colorectal carcinogenesis. PMID: 15245581
  17. Chibby is not likely to promote colorectal carcinoma tumor development or progression. PMID: 16570344
  18. CBY promotes adipocyte differentiation through inhibition of beta catenin signaling. PMID: 17403895
  19. intrinsically disordered TC-1 interacts with Cby via its transient helical structure PMID: 17905836
  20. 14-3-3epsilon and 14-3-3zeta are identified as Cby-binding partners. PMID: 18573912
  21. genes including CHIBBY involved in pediatric ependymomas. PMID: 18663750
  22. Alanine substitutions of two or more of four critical leucine residues within the C-terminal heptad repeats eliminate the Cby-Cby interaction. PMID: 19435523

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Subcellular Location
Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Golgi apparatus, trans-Golgi network.
Protein Families
Chibby family
Tissue Specificity
Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.
Database Links

HGNC: 1307

OMIM: 607757

KEGG: hsa:25776

STRING: 9606.ENSP00000216029

UniGene: Hs.334911

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