CCDC6 Antibody, Biotin conjugated

Code CSB-PA623068LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CCDC6 Polyclonal antibody
Uniprot No.
Target Names
CCDC6
Alternative Names
CCDC 6 antibody; CCDC6 antibody; CCDC6_HUMAN antibody; Coiled coil domain containing 6 antibody; Coiled coil domain containing protein 6 antibody; Coiled-coil domain-containing protein 6 antibody; D10S170 antibody; FLJ32286 antibody; H4 antibody; Papillary thyroid carcinoma encoded protein antibody; Papillary thyroid carcinoma-encoded protein antibody; Protein H4 antibody; PTC antibody; TPC antibody; TST 1 antibody; TST1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Coiled-coil domain-containing protein 6 protein (347-440AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. FGFR inhibitors, particularly BGJ398, are therapeutic options for cholangiocarcinoma patients harboring FGFR2-CCDC6 fusions. PMID: 27216979
  2. Our findings nevertheless suggest that CCDC6-RET fusions identified by multiplex testing are potential targets for nintedanib therapy. PMID: 26787234
  3. we propose that the amount of CCDC6 protein in primary tumors, as reported in lung, may depend on the impairment of the CCDC6 turnover due to altered protein-protein interaction and post-translational modifications PMID: 25885523
  4. Results show that RNA-binding protein EWS binds and regulates CCDC6 expression at RNA and protein levels. PMID: 25751255
  5. CCDC6 levels provide valuable insight for OS. PMID: 25302833
  6. the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth. PMID: 24059746
  7. Expression of the CCDC6-RET fusion gene in LC-2/ad cells was demonstrated by the mRNA and protein levels, and the genomic break-point was confirmed by genomic DNA sequencing. PMID: 23578175
  8. CCDC6 is associated with cAMP signaling by fine regulating CREB1 transcriptional activity in normal and transformed thyroid cells. PMID: 23145146
  9. CCDC6-RET fusion is associated with lung adenocarcinoma. PMID: 23154560
  10. It was shown that FBXW7 interacts with and targets CCDC6 for ubiquitin-mediated proteasomal degradation. FBXW7-mediated CCDC6 degradation was impaired in response to DNA damage. PMID: 23108047
  11. Following genotoxic stress, loss or inactivation of CCDC6 in cancers that carry the CCDC6 fusion, accelerates the dephosphorylation of pH2AX S139, resulting in defective G2 arrest and premature mitotic entry. PMID: 22655027
  12. CCDC6 plays a key role in cell cycle control. PMID: 22363533
  13. we discovered previously unidentified kinase fusions that may be promising for molecular-targeted therapy, kinesin family member 5B (KIF5B)-ret proto-oncogene (RET) and coiled-coil domain containing 6 (CCDC6)-RET, in 14 adenocarcinomas PMID: 22327623
  14. down-regulation of 14-3-3sigma in the absence of CCDC6 demonstrated their direct association and supports the notion that CCDC6 contributes to cancer development, possibly through malignant pathways involving 14-3-3sigma PMID: 22399611
  15. repression of CREB1 activity by CCDC6 has a critical function in the development of human thyroid papillary carcinomas carrying RET/PTC1 activation. PMID: 20498639
  16. H4(D10S170) is involved in the cellular response to ataxia telangectasia mutated (ATM) kinase; impairment of H4(D10S170) gene function might have a role in thyroid carcinogenesis. PMID: 17420723
  17. frequency of the occurrence of BRAF mutation and/or RET/PTC in H4-PTEN positive tumors was extremely high (75%) in papillary thyroid carcinoma PMID: 18226854
  18. PTC1 and PTC3 are highly oncogenic proteins when overexpressed, but result in indolent disease compared with RET-related MTCs due to their relatively low expression from the NCOA4 and CCDC6 promoters in vivo. PMID: 19487296

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Involvement in disease
A chromosomal aberration involving CCDC6 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Note=May be a cytoskeletal protein.
Tissue Specificity
Ubiquitously expressed.
Database Links

HGNC: 18782

OMIM: 601985

KEGG: hsa:8030

STRING: 9606.ENSP00000263102

UniGene: Hs.591360

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