CCNB1IP1 Antibody

Code CSB-PA002899
Size US$100
  • Western Blot analysis of COLO205 cells using HEI10 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
Alternative Names
C14orf18 antibody; CCNB1IP1 antibody; Chromosome 14 open reading frame 18 antibody; CIP1_HUMAN antibody; Cyclin B1 interacting protein 1 antibody; cyclin B1 interacting protein 1; E3 ubiquitin protein ligase antibody; Cyclin-B1-interacting protein 1 antibody; E3 ubiquitin-protein ligase CCNB1IP1 antibody; Enhancer of invasion 10 antibody; Gm288 antibody; HEI10 antibody; Human enhancer of invasion 10 antibody; mei4 antibody
Raised in
Species Reactivity
Synthesized peptide derived from the C-terminal region of Human HEI10.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.; E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Gene References into Functions
  1. HEI10 defines a divergent class of E3 ubiquitin ligase, functioning in progression through G(2)/M. PMID: 12612082
  2. The cyclin B-binding protein and cell cycle regulator HEI10 is identified as a novel merlin-binding partner; interaction with merlin affects HEI10 protein levels. PMID: 16532029
Subcellular Location
Nucleus. Chromosome. Note=Associates to the synaptonemal complex.
Tissue Specificity
Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
Database Links

HGNC: 19437

OMIM: 608249

KEGG: hsa:57820

STRING: 9606.ENSP00000337396

UniGene: Hs.107003

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