CCNL1 Antibody

Code CSB-PA001903
Size US$167
Image
  • Western Blot analysis of HepG2 cells using Cyclin L1 Polyclonal Antibody
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Product Details

Uniprot No. Q9UK58
Target Names CCNL1
Alternative Names CCNL1 antibody; BM-001 antibody; UNQ530/PRO1073 antibody; Cyclin-L1 antibody; Cyclin-L antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the C-terminal region of Human Cyclin L1.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs)
Gene References into Functions
  1. Results suggest that LEKR1-CCNL1 and IGSF21-KLHDC7A gene polymorphisms influence the development of diabetic retinopathy (DR). PMID: 27607899
  2. CCNL1 is the target gene of miR-199b-5p. PMID: 26043836
  3. Data indicate that if the newborn carried a risk allele rs900400 near LEKR/CCNL1, the impact of stress on birth size was stronger. PMID: 22685556
  4. birth weight lowering effect of the C-allele of rs900400 located near LEKR1 and CCNL1 was replicated in the Danish population. Furthermore the C-allele was associated with increased insulin response following oral glucose stimulation PMID: 22073261
  5. Data show low birth weight in Asian Indians is not due to variation near CCNL1/ADCY5, but variant ADCY5 is associated with elevated glucose/decreased insulin response which suggests a common genetic cause of low birth weight and risk of type 2 diabetes. PMID: 21712988
  6. These data demonstrate that there is a fine balance between CCNL1 and TIMP1, which may contribute to breast cancer development. PMID: 21586274
  7. Our results suggest that a genetic variant of ccnl1 leads to symmetric growth restriction from early pregnancy onward PMID: 21307140
  8. Cyclin L1 amplification is associated with uterine cervical carcinoma. PMID: 20721974
  9. variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight PMID: 20372150
  10. role in pre-mRNA splicing PMID: 11980906
  11. Our results indicate that CCNL1 plays a critical role in the loco-regional progression of HNSCC and may serve as an indicator for occult advanced tumour stages. PMID: 15700036
  12. study suggests that cyclin l1 may have a role in RNA processing complex anc ould participate in tumor progression of head and neck squamous cell carcinoma PMID: 16598186
  13. Data show that a green fluorescent protein (GFP) fusion protein of cyclin L1, in contrast to cyclin L2, was not mobile within the nucleus of living COS7 cells. PMID: 17494991
  14. CDK11(p110) interacts physically and functionally with cyclin Lalpha and -beta isoforms and SR proteins to regulate splicing. PMID: 18216018
  15. Cyclin L has been shown to associate with the PITSLRE kinase and is involved in pre-mRNA processing. PMID: 11980906

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Subcellular Location Nucleus speckle, Nucleus, nucleoplasm
Protein Families Cyclin family, Cyclin L subfamily
Tissue Specificity Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
Database Links

HGNC: 20569

OMIM: 613384

KEGG: hsa:57018

STRING: 9606.ENSP00000295926

UniGene: Hs.4859

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