Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Modulates negatively TGFB1 signaling in keratinocytes.
Gene References into Functions
GRP78 binds to and acts in concert with a glycosylphosphatidylinositol-anchored protein, CD109, in blocking TGF-beta signaling by promoting the routing of the TGF-beta receptor to the caveolae, thereby disrupting its binding to and activation of Smad2. PMID: 29654145
CD109 knockdown upregulated IL-8 expression through activation of TGF-beta/Akt/NF-kappaB pathway in human umbilical vein endothelial cells PMID: 27121053
High expression of CD109 in brain tumor stem cells is involved in glioma progression. PMID: 28888050
The CD109 protein was up-regulated in hepatocellular carcinoma tissue compared with adjacent noncancerous tissue. CD109 shRNA knockdown delayed the G1-S phase transition, abrogated cell proliferation, and increased cell apoptosis. Furthermore, CD109 impaired TGF-beta/Smad signaling through control of p-smad2. PMID: 27074923
CD109 is a putative biomarker for identifying a high-risk group among DLBCL patients. PMID: 28032275
Expression levels of CD109 was reduced significantly in psoriasis. Lower expression of CD109 and TGF-beta RI was highly correlated with higher expression of Smad7 and Ki67, suggesting that CD109 may induce the pathogenesis of psoriasis through Smad7-mediated degradation of TGF-beta RI. PMID: 26838754
sCD109 can bind TGF-beta, inhibit TGF-beta binding to its receptors and decrease TGF-beta signalling and TGF-beta-induced cellular responses. PMID: 26621871
These findings indicate that CD109 is an exosomal protein and that the C-terminal region of CD109 is required for its presence in the exosome. PMID: 26707640
CD109 may be a potential pathology marker for gallbladder squamous cell/adenosquamous carcinomas. PMID: 26249215
CD109 is specifically expressed in endothelial cells of cutaneous cavernous haemangioma. PMID: 25388101
expression increased in cutaneous squamous cell carcinoma PMID: 25271095
The results suggest that circulating endothelial cells express CD109 and represent a rare population of circulating tumor endothelial cells, that play a potentially useful prognostic role in patients with glioblastoma. PMID: 25506915
CD109 overexpression was significantly associated with surgical stage, distant metastasis, and poor prognosis in myxofibrosarcoma. PMID: 26031650
Three glioblastoma cell lines, SK-MG-1, U251MG and MG178, were tested and CD109 overexpression attenuated TGF-beta1 signaling and enhanced EGF signaling in SK-MG-1, but not in U251MG or MG178. PMID: 25724945
CD109 is highly expressed in TNBC and is a potential biomarker for the initiation, progression, and differentiation of breast cancer tumors. PMID: 25149155
CD109 plays a critical role in non-small-cell lung cancer (NSCLC) progression, and is overexpressed in advanced NSCLC PMID: 24667143
High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in a novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma. PMID: 24376795
Hematopoietic cell marker CD109 is expressed in hepatic progenitor cells. PMID: 24396288
expression of CD109 (human platelet antigen 15) mRNA is different in various human cell types PMID: 23509816
The upregulation of CD109 protein in SSc may represent an adaptation or consequence of aberrant TGF-beta signaling in systemic sclerosis PMID: 22694813
CD109 is an important regulator of SMAD7/Smurf2-mediated degradation of TGFBR1. PMID: 21898545
CD109 release from the cell surface in human keratinocytes regulates TGF-beta receptor expression, TGF-beta signalling and STAT3 activation. PMID: 21539622
CD109 regulates TGF-beta receptor endocytosis and degradation to inhibit TGF-beta signaling. PMID: 21295082
Report PRSS3/mesotrypsin upregulation in breast cancer cells and identify CD109 as the functional proteolytic target of mesotrypsin. PMID: 20035377
These findings suggest that CD109 is involved in bladder tumorigenesis and is a potential target for cancer immunotherapy. PMID: 20946523
Processing of CD109 into 180 kDa and 25 kDa proteins by furin, followed by complex formation with the type I TGF-beta receptor is required for the regulation of TGF-beta signaling in cancer cells and keratinocytes. PMID: 20101215
Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins. cDNA sequence determination and protein structure analysis given. PMID: 11861284
A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens. PMID: 11861285
Findings suggest that CD109 may become a molecular target for the development of new therapeutics for squamous cell carcinoma of various tissue origins. PMID: 15826242
CD109 plays a unique role in the regulation of isoform-specific TGF-beta signaling in keratinocytes. PMID: 16754747
Findings indicate that CD109 is a useful marker for the diagnosis of invasive breast and prostate carcinomas. PMID: 17493171
the novel gene HEPT3 may function through its noncoding RNA and its overexpression may play a role in hepatocarcinogenesis [HEPT3] PMID: 17611685
CD109 expression may play a role in the development of lung squamous cell carcinoma. PMID: 17922683
Up-regulation of CD109 expression is associated with carcinogensis of the squamous epithelium of the oral cavity. PMID: 19016750
Found with a mutation in 7% of colon cancers studied. PMID: 16959974
Show More
Hide All
Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Protein Families
Protease inhibitor I39 (alpha-2-macroglobulin) family
Tissue Specificity
Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and act