CDAN1 Antibody

Datasheet

Code	CSB-PA810285LA01HU
Size	US$166
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Image	IHC image of CSB-PA810285LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA810285LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of SH-SY5Y cells with CSB-PA810285LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CDAN1 Polyclonal antibody

Uniprot No.

Q8IWY9

Target Names

CDAN1

Alternative Names

CDA1 antibody; CDAI antibody; CDAN1 antibody; CDAN1_HUMAN antibody; Codanin antibody; Codanin-1 antibody; Codanin1 antibody; PRO1295 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Codanin-1 protein (62-249AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CDAN1 Antibody (Product code: CSB-PA810285LA01HU) is Non-conjugated. For CDAN1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA810285LB01HU	CDAN1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA810285LC01HU	CDAN1 Antibody, FITC conjugated
Biotin	CSB-PA810285LD01HU	CDAN1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May act as a negative regulator of ASF1 in chromatin assembly.

Gene References into Functions

Mutation in CDAN1 gene is associated with congenital dyserythropoietic anemia. PMID: 29031773
The missense substitution in CDAN1, C15ORF41, encodes a novel restriction endonuclease in congenital dyserythropoietic anemia type I. PMID: 23716552
The proband with congenital dyserythropoietic anemia Iota in the first family was a compound heterozygote of CDAN1 with mutation IVS-12+2T>C and c. 3389C>T. PMID: 24196372
The authors propose that Codanin-1 acts as a negative regulator of Asf1 function in chromatin assembly. PMID: 22407294
A link between mutant codanin-1 and the aberrant localization of HP1 alpha is supported by the finding that codanin-1 can be coimmunoprecipitated by anti-HP1 alpha antibodies erythroblasts from patients with congenital dyserythropoietic anemia type 1. PMID: 21364188
Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1 PMID: 12434312
codanin-1 may play a role in the development of the skeleton. PMID: 16767397
This second case of retinal angioid streaks in CDA I reports a patient homozygous for the Arg1042Trp mutation in codanin-1. PMID: 18081704
Congenital dyserythropoietic anemia I (CDA I) is a well-defined entity within the heterogeneous group of the CDAN1 family; here it is associated with mutations in a Chinese family. PMID: 18575862
Data suggest that codanin-1 is a cell cycle-regulated protein active in the S phase. PMID: 19336738

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Involvement in disease

Anemia, congenital dyserythropoietic, 1A (CDAN1A)

Subcellular Location

Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein. Note=Mainly detected as a cytoplasmic protein.

Tissue Specificity

Ubiquitously expressed. Isoform 3 is not found in erythroid cells.

Database Links

HGNC: 1713

OMIM: 224120

KEGG: hsa:146059

STRING: 9606.ENSP00000348564

UniGene: Hs.599232

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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