Recombinant Human Codanin-1 (CDAN1), partial

Code CSB-YP810285HU
MSDS
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Source Yeast
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Code CSB-EP810285HU
MSDS
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Source E.coli
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Code CSB-EP810285HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP810285HU
MSDS
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Source Baculovirus
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Code CSB-MP810285HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CDAN1
Uniprot No.
Alternative Names
CDA1; CDAI; CDAN1; CDAN1_HUMAN; Codanin; Codanin-1; Codanin1; PRO1295
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
May act as a negative regulator of ASF1 in chromatin assembly.
Gene References into Functions
  1. Mutation in CDAN1 gene is associated with congenital dyserythropoietic anemia. PMID: 29031773
  2. The missense substitution in CDAN1, C15ORF41, encodes a novel restriction endonuclease in congenital dyserythropoietic anemia type I. PMID: 23716552
  3. The proband with congenital dyserythropoietic anemia Iota in the first family was a compound heterozygote of CDAN1 with mutation IVS-12+2T>C and c. 3389C>T. PMID: 24196372
  4. The authors propose that Codanin-1 acts as a negative regulator of Asf1 function in chromatin assembly. PMID: 22407294
  5. A link between mutant codanin-1 and the aberrant localization of HP1 alpha is supported by the finding that codanin-1 can be coimmunoprecipitated by anti-HP1 alpha antibodies erythroblasts from patients with congenital dyserythropoietic anemia type 1. PMID: 21364188
  6. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1 PMID: 12434312
  7. codanin-1 may play a role in the development of the skeleton. PMID: 16767397
  8. This second case of retinal angioid streaks in CDA I reports a patient homozygous for the Arg1042Trp mutation in codanin-1. PMID: 18081704
  9. Congenital dyserythropoietic anemia I (CDA I) is a well-defined entity within the heterogeneous group of the CDAN1 family; here it is associated with mutations in a Chinese family. PMID: 18575862
  10. Data suggest that codanin-1 is a cell cycle-regulated protein active in the S phase. PMID: 19336738

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Involvement in disease
Anemia, congenital dyserythropoietic, 1A (CDAN1A)
Subcellular Location
Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein. Note=Mainly detected as a cytoplasmic protein.
Tissue Specificity
Ubiquitously expressed. Isoform 3 is not found in erythroid cells.
Database Links

HGNC: 1713

OMIM: 224120

KEGG: hsa:146059

STRING: 9606.ENSP00000348564

UniGene: Hs.599232

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