CDK10 Antibody

1. The present study illustrated that downregulation of CDK10 expression activated Snaildriven EMT and consequently promoted glioma metastasis, suggesting that CDK10 may serve as a potential molecular target for glioma therapy. PMID: 29845196
2. the results of the present study indicated that CDK10 expression may serve as a novel prognostic biomarker that holds therapeutic promise for gastric cancer. PMID: 29512714
3. The findings of this study indicate that CDK10 plays a role in the pathogenesis in colorectal cancer and may be a potential therapeutic target for treatment. PMID: 28663269
4. These findings underscore the importance of CDK10 for the regulation of ciliogenesis. CDK10 defect is likely associated with a new form of ciliopathy phenotype; additional patients may further validate this association PMID: 29130579
5. CDK10 Mutations are associated with Severe Growth Retardation, Spine Malformations, and Developmental Delays. PMID: 28886341
6. CDK10/CycM is a key regulator of actin dynamics and a suppressor of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. PMID: 27104747
7. Down-regulated CDK10 expression frequently occurs in breast cancers and correlates with disease progression and poor survival PMID: 26392360
8. Results found that CDK10 mRNA expression was up-regulated in advanced breast neoplasm and positively correlated with C1orf63, which was consistent with the relationship of protein expression between C1orf63 and CDK10. PMID: 26209438
9. Data suggest that reactivation of CDK10 might be utilized as a novel epigenetic strategy for the treatment of nasopharyngeal carcinomas (NPC) patients. PMID: 23740091
10. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. PMID: 24218572
11. Data show that peptidyl-prolyl isomerase Pin1 silencing in SKBR-3 and MCF7 cells increased the cyclin-dependent kinase 10 (CDK10) expression. PMID: 22158035
12. CDK10 plays a crucial role in the growth and survivability of biliary tract cancer. PMID: 22209942
13. reduced Cdk10 expression is closely linked to hepatocellular carcinoma development and progression PMID: 22326270
14. CDK10 is not a target for aberrant DNA methylation in breast cancer. PMID: 19846932

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HGNC: 1770

OMIM: 603464

KEGG: hsa:8558

STRING: 9606.ENSP00000338673

UniGene: Hs.699177