Name: CDK10 Antibody
Brand: CUSABIO
SKU: CSB-PA001532

Product Details

Uniprot No.

Q15131

Target Names

CDK10

Alternative Names

CDC2 related protein kinase antibody; Cdk10 antibody; CDK10_HUMAN antibody; Cell division protein kinase 10 antibody; Cyclin dependent kinase 10 antibody; Cyclin dependent kinase related protein antibody; Cyclin-dependent kinase 10 antibody; PISSLRE antibody; Serine/threonine protein kinase PISSLRE antibody; Serine/threonine-protein kinase PISSLRE antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human Cdk10.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:10000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Data

Function	Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells)
Gene References into Functions	The present study illustrated that downregulation of CDK10 expression activated Snaildriven EMT and consequently promoted glioma metastasis, suggesting that CDK10 may serve as a potential molecular target for glioma therapy. PMID: 29845196 the results of the present study indicated that CDK10 expression may serve as a novel prognostic biomarker that holds therapeutic promise for gastric cancer. PMID: 29512714 The findings of this study indicate that CDK10 plays a role in the pathogenesis in colorectal cancer and may be a potential therapeutic target for treatment. PMID: 28663269 These findings underscore the importance of CDK10 for the regulation of ciliogenesis. CDK10 defect is likely associated with a new form of ciliopathy phenotype; additional patients may further validate this association PMID: 29130579 CDK10 Mutations are associated with Severe Growth Retardation, Spine Malformations, and Developmental Delays. PMID: 28886341 CDK10/CycM is a key regulator of actin dynamics and a suppressor of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. PMID: 27104747 Down-regulated CDK10 expression frequently occurs in breast cancers and correlates with disease progression and poor survival PMID: 26392360 Results found that CDK10 mRNA expression was up-regulated in advanced breast neoplasm and positively correlated with C1orf63, which was consistent with the relationship of protein expression between C1orf63 and CDK10. PMID: 26209438 Data suggest that reactivation of CDK10 might be utilized as a novel epigenetic strategy for the treatment of nasopharyngeal carcinomas (NPC) patients. PMID: 23740091 CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. PMID: 24218572 Data show that peptidyl-prolyl isomerase Pin1 silencing in SKBR-3 and MCF7 cells increased the cyclin-dependent kinase 10 (CDK10) expression. PMID: 22158035 CDK10 plays a crucial role in the growth and survivability of biliary tract cancer. PMID: 22209942 reduced Cdk10 expression is closely linked to hepatocellular carcinoma development and progression PMID: 22326270 CDK10 is not a target for aberrant DNA methylation in breast cancer. PMID: 19846932 Show More Hide All
Involvement in disease	Al Kaissi syndrome (ALKAS)
Subcellular Location	Cytoplasm, cytoskeleton, cilium basal body
Protein Families	Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Database Links	HGNC: 1770 OMIM: 603464 KEGG: hsa:8558 STRING: 9606.ENSP00000338673 UniGene: Hs.699177

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Check Code：

Code	CSB-PA001532
Size	US$167
Image	Western Blot analysis of 293 cells using Cdk10 Polyclonal Antibody Western Blot analysis of RAT-Intestine cells using Cdk10 Polyclonal Antibody
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CDK10 Antibody

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Target Data

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