CDK10 Antibody

Code CSB-PA001532
Size US$167
Image
  • Western Blot analysis of 293 cells using Cdk10 Polyclonal Antibody
  • Western Blot analysis of RAT-Intestine cells using Cdk10 Polyclonal Antibody
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Product Details

Uniprot No. Q15131
Target Names CDK10
Alternative Names CDC2 related protein kinase antibody; Cdk10 antibody; CDK10_HUMAN antibody; Cell division protein kinase 10 antibody; Cyclin dependent kinase 10 antibody; Cyclin dependent kinase related protein antibody; Cyclin-dependent kinase 10 antibody; PISSLRE antibody; Serine/threonine protein kinase PISSLRE antibody; Serine/threonine-protein kinase PISSLRE antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the Internal region of Human Cdk10.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells)
Gene References into Functions
  1. The present study illustrated that downregulation of CDK10 expression activated Snaildriven EMT and consequently promoted glioma metastasis, suggesting that CDK10 may serve as a potential molecular target for glioma therapy. PMID: 29845196
  2. the results of the present study indicated that CDK10 expression may serve as a novel prognostic biomarker that holds therapeutic promise for gastric cancer. PMID: 29512714
  3. The findings of this study indicate that CDK10 plays a role in the pathogenesis in colorectal cancer and may be a potential therapeutic target for treatment. PMID: 28663269
  4. These findings underscore the importance of CDK10 for the regulation of ciliogenesis. CDK10 defect is likely associated with a new form of ciliopathy phenotype; additional patients may further validate this association PMID: 29130579
  5. CDK10 Mutations are associated with Severe Growth Retardation, Spine Malformations, and Developmental Delays. PMID: 28886341
  6. CDK10/CycM is a key regulator of actin dynamics and a suppressor of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. PMID: 27104747
  7. Down-regulated CDK10 expression frequently occurs in breast cancers and correlates with disease progression and poor survival PMID: 26392360
  8. Results found that CDK10 mRNA expression was up-regulated in advanced breast neoplasm and positively correlated with C1orf63, which was consistent with the relationship of protein expression between C1orf63 and CDK10. PMID: 26209438
  9. Data suggest that reactivation of CDK10 might be utilized as a novel epigenetic strategy for the treatment of nasopharyngeal carcinomas (NPC) patients. PMID: 23740091
  10. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. PMID: 24218572
  11. Data show that peptidyl-prolyl isomerase Pin1 silencing in SKBR-3 and MCF7 cells increased the cyclin-dependent kinase 10 (CDK10) expression. PMID: 22158035
  12. CDK10 plays a crucial role in the growth and survivability of biliary tract cancer. PMID: 22209942
  13. reduced Cdk10 expression is closely linked to hepatocellular carcinoma development and progression PMID: 22326270
  14. CDK10 is not a target for aberrant DNA methylation in breast cancer. PMID: 19846932

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Involvement in disease Al Kaissi syndrome (ALKAS)
Subcellular Location Cytoplasm, cytoskeleton, cilium basal body
Protein Families Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Database Links

HGNC: 1770

OMIM: 603464

KEGG: hsa:8558

STRING: 9606.ENSP00000338673

UniGene: Hs.699177

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