CDK5R2 Antibody

Code CSB-PA003663
Size US$100
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  • Western Blot analysis of HuvEc cells using p39 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CDK5R2
Alternative Names
CD5R2_HUMAN antibody; CDK5 activator 2 antibody; Cdk5r2 antibody; Cyclin dependent kinase 5 activator 2 antibody; Cyclin dependent kinase 5 activator isoform p39i antibody; Cyclin dependent kinase 5 regulatory subunit 2 antibody; Cyclin-dependent kinase 5 activator 2 antibody; Cyclin-dependent kinase 5 regulatory subunit 2 antibody; NCK5AI antibody; Neuronal CDK5 activator isoform antibody; p39 antibody; P39I antibody; p39nck5ai antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human p39.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Activator of CDK5/TPKII.
Gene References into Functions
  1. p39 is essential for recruiting scaffolding protein muskelin to stress fibers. PMID: 25128817
  2. Hepatocellular carcinoma patients with lower p39 expression had poorer overall survival rate than that with high expression. PMID: 20936377
  3. Our data suggest that neurotoxic insults lead to calpain-mediated conversion of p39 to p29, which might contribute to deregulation of Cdk5 PMID: 11784720
  4. role of the CDK5 molecular complex in the genetic etiology of early-onset Alzheimer disease; a yet unknown functional variant in CDK5 or in a nearby gene might lead to increased susceptibility for early-onset Alzheimer disease PMID: 15917097
Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein Families
Cyclin-dependent kinase 5 activator family
Tissue Specificity
Brain and neuron specific.
Database Links

HGNC: 1776

OMIM: 603764

KEGG: hsa:8941

STRING: 9606.ENSP00000304250

UniGene: Hs.158460

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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