CELF5 Antibody

Datasheet
Code CSB-PA002824GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. Q8N6W0
Immunogen Human BRUNOL5
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity Purified
Isotype IgG
Alias bruno-like 5, RNA binding protein (Drosophila);BRUNOL5;BRUNOL-5;CELF5 ;
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Target Names CELF5
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation.
HGNC 14058
RGD 1565016
MGI 2442333
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Function RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
Subcellular Location Nucleus, Cytoplasm
Protein Families CELF/BRUNOL family
Tissue Specificity Expressed in brain.
Database Links

HGNC: 14058

OMIM: 612680

KEGG: hsa:60680

STRING: 9606.ENSP00000292672

UniGene: Hs.655747

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