CELSR3 Antibody

Datasheet

Code	CSB-PA852817LA01HU
Size	US$166
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Image	IHC image of CSB-PA852817LA01HU diluted at 1:300 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CELSR3 Polyclonal antibody

Uniprot No.

Q9NYQ7

Target Names

CELSR3

Alternative Names

Anchor protein antibody; Cadherin EGF LAG seven-pass G-type receptor 3 antibody; Cadherin family member 11 antibody; CDHF11 antibody; CELR3_HUMAN antibody; Celsr3 antibody; EGF like domain multiple 1 antibody; EGF-like protein 1 antibody; EGFL1 antibody; Epidermal growth factor-like protein 1 antibody; Flamingo antibody; Flamingo homolog 1 antibody; FMI1 antibody; hFmi1 antibody; MEGF2 antibody; Multiple EGF-like domains protein 2 antibody; Multiple epidermal growth factor-like domains protein 2 antibody; RESDA1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 3 protein (514-718AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CELSR3 Antibody (Product code: CSB-PA852817LA01HU) is Non-conjugated. For CELSR3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA852817LB01HU	CELSR3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA852817LC01HU	CELSR3 Antibody, FITC conjugated
Biotin	CSB-PA852817LD01HU	CELSR3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Receptor that may have an important role in cell/cell signaling during nervous system formation.

Gene References into Functions

Study identifies four likely Tourette disorder risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3), NIPBL (Nipped-B-like), and FN1 (fibronectin 1). PMID: 28472652
marked reduction in the prominence of TUJ1 bundles in number, thickness, and length. Our results showed that deregulation of the planar cell polarity genes CELSR3 and FZD3 might disrupt the enteric innervation pattern PMID: 27619161
A moderate positive correlation between CELSR3 and patient age was also evident. PMID: 26838213
seven-transmembrane domain receptors Celsr3 and Fzd3, in particular, control the development of most longitudinal tracts in the central nervous system. [Review] PMID: 25813877
CELSR3 promoter hypermethylation is associated with oral squamous cell carcinoma. PMID: 25374236
CELSR3 was found to be selectively up-regulated in tumor stellate cells. PMID: 20416094
CELSR3 is one of the core PCP signaling molecules. PMID: 16273260

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 2 family, LN-TM7 subfamily

Database Links

HGNC: 3230

OMIM: 604264

KEGG: hsa:1951

STRING: 9606.ENSP00000164024

UniGene: Hs.631926

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Email: [email protected]
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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

G protein coupled receptor signaling pathway Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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