CENPF Antibody

1. This is the second case report identifying CENPF mutation as the cause of Stromme syndrome PMID: 28407396
2. Authors suggest that CENP-F might act as a transporter of mitochondria and other cellular cargoes by attaching them to dynamic microtubule ends during both polymerization and depolymerization of tubulin. PMID: 28701340
3. Tumors with higher topoisomerase IIalpha and/or mitosin expression have a higher risk of recurrence after initial treatment, and these patients may benefit from adjuvant treatment and closer radiological follow-up PMID: 28301542
4. We show for the first time that Stromme syndrome is an autosomal-recessive disease caused by mutations in CENPF that can result in a wide phenotypic spectrum. PMID: 26820108
5. Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells. PMID: 26259702
6. Mitosin and pHH3 immunostaining predict poorer survival in astrocytomas WHO grades II and III. PMID: 26188054
7. Our data identify CENPF as a new centriolar disease gene implicated in severe human ciliopathy and microcephaly related phenotypes PMID: 25564561
8. the increased expression of CENPF plays an important role in the progression of PCa. PMID: 25647485
9. N-terminal microtubule-binding domain of CENP-F prefers curled oligomers of tubulin relative to microtubule walls by approximately fivefold, suggesting it may contribute to the firm bonds between kinetochores and flared plus ends of dynamic microtubules PMID: 26101217
10. FOXM1 and CENPF function synergistically to promote tumor growth by coordinated regulation of target gene expression and activation of key signaling pathways associated with prostate cancer malignancy. PMID: 24823640
11. CENP-F may serve as valuable molecular marker for predicting prognosis of ESCC patients. data indicate potential benefit of combining ZOL with cisplatin in ESCC; CENP-F expressionmay have therapeutic implications. PMID: 23163484
12. data suggest that CENPF is frequently overexpressed in HCC and plays a critical role in driving HCC tumorigenesis PMID: 23791740
13. Data suggest that ASUN promotes perinuclear enrichment of dynein at G2/M that facilitates BICD2- and CENP-F-mediated anchoring of dynein to nuclear pore complexes. PMID: 23097494
14. Coincidently amplified CDK13, GMNN, and CENPF genes can play a role as common cancer-driver genes in human cancers. PMID: 22912832
15. Rab5 forms a complex with a subset of CENP-F in mitotic cells and regulates the kinetics of release of CENP-F from the nuclear envelope and its accumulation on kinetochores. PMID: 21987812
16. Centromere protein F and survivin are malignant behaviour markers for colorectal gastrointestinal stromal tumours. PMID: 21613637
17. Data identified Cenp-F as a potential new molecular target for NBPs in tumour cells. PMID: 20015195
18. Cenp-F plays a role in organization of interphase chromatin through association and possibly regulation of DNA-PK. PMID: 20978035
19. Data suggest that CENP-F protein is a valuable marker of nasopharyngeal carcinoma progression, and CENP-F expression is associated with poor overall survival of patients. PMID: 20828406
20. Mitosin did not predict patient survival in this series of cutaneous melanomas. PMID: 20398247
21. These results uncover a novel role of CENP-F in regulation of epigenetic modification on histone H3. PMID: 20213041
22. Data show that the post-anaphase, KEN-box-dependent degradation of Cenp-F requires it to be farnesylated, a post-translational modification usually linked to membrane association. PMID: 20053638
23. Data suggest that farnesylation of Cenp-F is required not only for its localisation to the nuclear envelope and kinetochores but also for timely progression through G2/M and its degradation after mitosis. PMID: 12154071
24. Data show that mitosin associates preferentially with kinetochores of unaligned chromosomes. PMID: 12974617
25. CENP-F expression presents a theoretical advantage for the analysis of the precise cell cycle of G2 to M cells, compared to Ki-67. PMID: 14720137
26. Results suggest that mitosin is a negative regulator of ATF4 in interphase through direct interaction. PMID: 15677469
27. Mitosin is therefore essential for full chromosome alignment, possibly by promoting proper kinetochore attachments through modulating CENP-E and dynein functions PMID: 15870278
28. In addition to regulating kinetochore-microtubule interactions, Cenp-F might be required to protect centromeric cohesion prior to anaphase commitment. PMID: 16219694
29. Data show that the absence of nuclear CENP-F does not affect cell cycle progression in S and G2, and that CENP-F is crucial for efficient assembly of a stable microtubule-kinetochore interface. PMID: 16252009
30. REVIEW: involvement in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. PMID: 16456711
31. CENP-F is a novel microtubule-binding protein that possesses two microtubule-binding domains at opposite ends of the molecule. The C-terminal microtubule-binding domain was found to stimulate microtubule polymerization in vitro. PMID: 16601978
32. CENP-F upregulation was significantly associated breast cancer PMID: 17205517
33. Ndel1, Nde1, and Lis1 localize to kinetochores in a Cenp-F-dependent manner. PMID: 17600710
34. high expression levels of the CENP-F appeared to be the molecular background of higher proliferative activity, and they were correlated with high SUV (standardized uptake value) in breast cancer PMID: 19102762

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HGNC: 1857

OMIM: 243605

KEGG: hsa:1063

STRING: 9606.ENSP00000355922

UniGene: Hs.497741