CENPH Antibody

1. In summary, CENP-H may be involved in cell proliferation and apoptosis of hepatocellular carcinoma (HCC)cells through the mitochondrial apoptotic pathway. Combined with previous studies, the data provide a new perspective on HCC development and progression. PMID: 28498417
2. Upregulation of centromere protein H is associated with progression of renal cell carcinoma PMID: 26248586
3. propose that CSPP1 cooperates with CENP-H on kinetochores to serve as a novel regulator of kinetochore microtubule dynamics for accurate chromosome segregation PMID: 26378239
4. CENP-H was overexpressed in HCC, and its level of upregulation was an independent prognostic indicator, suggesting that CENP-H may be an effective therapeutic strategy for the treatment of HCC. PMID: 23970101
5. CENP-H promotes the proliferation of human gastric cancer cells PMID: 22381774
6. High expression of CENP-H in gastric cancer indicates poor prognosis and Survivin may mediate its procancer role. PMID: 22999412
7. Breast cancer patients with high CENP-H expression had short overall survival. CENP-H expression was related with clinical stage. PMID: 21880184
8. upregulated CENP-H and Ki67 levels are significantly associated with short relapse-free survival in hypopharyngeal squamous cell carcinoma (HSSC); these factors may be predictors of a relapsing phenotype in HSSC cases PMID: 22631655
9. Sp1 and Sp3 bind to the CENPH minimal promoter and function as a regulator of the transcription of CENPH in nasopharyngeal carcinomas. PMID: 22682030
10. CENP-H is up-regulated and plays an important role in the aneuploidy frequently observed in colorectal cancers. PMID: 15930286
11. The CENP-H-I complex may function, in part, as a marker directing CENP-A deposition to centromeres. PMID: 16622420
12. has an important impact on the architecture and function of the human kinetochore complex PMID: 16875666
13. CENP-H has a role in preventing progression of nasopharyngeal carcinoma PMID: 17255272
14. CENP-C and CENP-H co-localize to the CENP-A chromatin domain. PMID: 17651496
15. CENP-H protein has a role in esophageal carcinoma progression PMID: 18700042
16. expression of CENPH was much higher in cancer cell lines & lung cancer tissue than normal cells & adjacent noncancerous lung tissues; results show that high CENPH protein expression was related to poor outcome in patients with nonsmall cell lung cancer PMID: 19170237
17. TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H. PMID: 19232519
18. Upregulation of CENP-H in tongue cancer is associated with disease progression. PMID: 19500341
19. CENP-H-containing complex facilitates deposition of newly synthesized CENP-A into centromeric chromatin in cooperation with FACT and CHD1. PMID: 19625449

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HGNC: 17268

OMIM: 605607

KEGG: hsa:64946

STRING: 9606.ENSP00000283006

UniGene: Hs.631967