CENPK Antibody

Datasheet

Code	CSB-PA005214ESR2HU
Size	US$166
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Image	Western blot All lanes: CENPK antibody at 4.17µg/ml Lane 1: PC-3 whole cell lysate Lane 2: 293T whole cell lysate Lane 3: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 32 kDa Observed band size: 32 kDa Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA005214ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA005214ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CENPK Polyclonal antibody

Uniprot No.

Q9BS16

Target Names

CENPK

Alternative Names

CENPK antibody; ICEN37 antibody; FKSG14 antibody; Centromere protein K antibody; CENP-K antibody; Interphase centromere complex protein 37 antibody; Protein AF-5alpha antibody; p33 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Centromere protein K protein (1-269AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore.

Involvement in disease

Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1.

Subcellular Location

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Protein Families

CENP-K/MCM22 family

Tissue Specificity

Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta.

Database Links

HGNC: 29479

OMIM: 611502

KEGG: hsa:64105

STRING: 9606.ENSP00000242872

UniGene: Hs.529778

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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