CENPU Antibody

1. In-depth IPA analysis revealed that CENPU was associated with the HMGB1 signaling pathway. qPCR and western blot analysis demonstrated that in the HMGB1 signaling pathway, CENPU knockdown downregulated expression levels of ILB, CXCL8, RAC1 and IL1A PMID: 28677729
2. This study provides new insights and evidences that MLF1IP over-expression plays important roles in progression of luminal breast cancer. However, the precise cellular mechanisms for MLF1IP in luminal breast cancer need to be further explored. PMID: 27378428
3. MLF1IP promotes normal erythroid proliferation and is involved in the pathogenesis of polycythemia vera. PMID: 28173615
4. MLF1IP significantly promotes prostate cancer cell proliferation and colony formation and significantly inhibits apoptosis without affecting cell cycle phase arrest in prostate cancer cell lines PMID: 25572810
5. CENP-U is a novel microtubule binding protein and plays an important role in kinetochore-microtubule attachment through its interaction with Hec1 PMID: 21056971
6. a possible role for MLF1IP deregulation in the genesis of erythroleukemias PMID: 15116101
7. MLF1IP was found in glioblastomas where it was co-localized with MLF1 and nestin. Moreover, it was elevated in the contralateral brain where no tumor cells occurred, suggesting a role in glioma pathogenesis and potentially in other types of malignancies. PMID: 15893739
8. Plk1 self-regulates the Plk1-PBIP1 interaction to timely localize to the kinetochores and promote proper chromosome segregation. PMID: 17081991
9. Deletion mutants of MLF1IP revealed that the N-terminal bipartite nuclear localization signal (NLS) was responsible for nucleolar targeting. PMID: 17595757

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HGNC: 21348

OMIM: 611511

KEGG: hsa:79682

STRING: 9606.ENSP00000281453

UniGene: Hs.575032