CEP57 Antibody

Datasheet

Code	CSB-PA769805DSR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA769805DSR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CEP57 Polyclonal antibody

Uniprot No.

Q86XR8

Target Names

CEP57

Alternative Names

Centrosomal protein 57kDa antibody; Centrosomal protein of 57 kDa antibody; Cep57 antibody; Cep57 protein antibody; CEP57_HUMAN antibody; FGF2 interacting protein antibody; FGF2-interacting protein antibody; KIAA0092 antibody; MVA2 antibody; PIG8 antibody; Proliferation inducing protein 8 antibody; Testis specific protein 57 antibody; Testis-specific protein 57 antibody; Translokin antibody; TSP57 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Centrosomal protein of 57 kDa protein (1-240AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.

Gene References into Functions

Cep57 is a mitotic kinetochore component that links the function of the KMN (KNL1/Mis12 complex/Ndc80 complex) network and spindle assembly checkpoint via Mis12 binding and Mad1-Mad2 interaction. PMID: 26743940
We identified copy number variation (CNV) deletion impacting the exon sequences of CEP57L1, present in the affected mother and her affected daughter PMID: 26561035
Cep57, Cep63, and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles. PMID: 23333316
Cep57 is essential for cytokinesis via regulation of central spindle assembly and formation of the midbody PMID: 23569207
Data suggest for therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer. PMID: 23243019
Cep57 acts as a PCM component through binding to NEDD1 and is required for spindle microtubule organization and maintenance of spindle pole integrity. PMID: 22508265
Our findings indicate that these and/or additional functions of CEP57 are crucial for maintaining correct chromosomal number during cell division. PMID: 21552266

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Involvement in disease

Mosaic variegated aneuploidy syndrome 2 (MVA2)

Subcellular Location

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Protein Families

Translokin family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 30794

OMIM: 607951

KEGG: hsa:9702

STRING: 9606.ENSP00000317902

UniGene: Hs.101014

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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