CEP57 Antibody

Code CSB-PA080051
Size US$100
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Product Details

Uniprot No.
Target Names
CEP57
Alternative Names
Centrosomal protein 57kDa antibody; Centrosomal protein of 57 kDa antibody; Cep57 antibody; Cep57 protein antibody; CEP57_HUMAN antibody; FGF2 interacting protein antibody; FGF2-interacting protein antibody; KIAA0092 antibody; MVA2 antibody; PIG8 antibody; Proliferation inducing protein 8 antibody; Testis specific protein 57 antibody; Testis-specific protein 57 antibody; Translokin antibody; TSP57 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human CEP57.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.
Gene References into Functions
  1. Cep57 is a mitotic kinetochore component that links the function of the KMN (KNL1/Mis12 complex/Ndc80 complex) network and spindle assembly checkpoint via Mis12 binding and Mad1-Mad2 interaction. PMID: 26743940
  2. We identified copy number variation (CNV) deletion impacting the exon sequences of CEP57L1, present in the affected mother and her affected daughter PMID: 26561035
  3. Cep57, Cep63, and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles. PMID: 23333316
  4. Cep57 is essential for cytokinesis via regulation of central spindle assembly and formation of the midbody PMID: 23569207
  5. Data suggest for therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer. PMID: 23243019
  6. Cep57 acts as a PCM component through binding to NEDD1 and is required for spindle microtubule organization and maintenance of spindle pole integrity. PMID: 22508265
  7. Our findings indicate that these and/or additional functions of CEP57 are crucial for maintaining correct chromosomal number during cell division. PMID: 21552266

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Involvement in disease
Mosaic variegated aneuploidy syndrome 2 (MVA2)
Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein Families
Translokin family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 30794

OMIM: 607951

KEGG: hsa:9702

STRING: 9606.ENSP00000317902

UniGene: Hs.101014

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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