CES3 Antibody

Code CSB-PA005260LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA005260LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA005260LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA005260LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CES3 Polyclonal antibody
Uniprot No.
Target Names
CES3
Alternative Names
Carboxylesterase 3 antibody; CES 3 antibody; Ces3 antibody; ES3 antibody; EST3_HUMAN antibody; FLJ21736 antibody; Liver carboxylesterase 31 homolog antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Carboxylesterase 3 protein (65-233AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CES3 Antibody (Product code: CSB-PA005260LA01HU) is Non-conjugated. For CES3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA005260LB01HU CES3 Antibody, HRP conjugated ELISA
FITC CSB-PA005260LC01HU CES3 Antibody, FITC conjugated
Biotin CSB-PA005260LD01HU CES3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
Gene References into Functions
  1. This study provides the first evidence of functional compensation whereby increased expression of CES3 restores intracellular cholesteryl ester hydrolytic activity and free cholesterol efflux in CES1-deficient cells. PMID: 22700792
  2. Studies indicate that CES3 mRNA isoform expression in several tissues, particularly in colon, trachea and in brain. PMID: 20422440
  3. CES3 seems to have a lower catalytic efficiency than the other two CESs for selected substrates. PMID: 19508181
  4. pharmacogenomic characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes PMID: 18794728
Subcellular Location
Endoplasmic reticulum lumen.
Protein Families
Type-B carboxylesterase/lipase family
Tissue Specificity
Expressed in liver, colon and small intestine.
Database Links

HGNC: 1865

OMIM: 605279

KEGG: hsa:23491

STRING: 9606.ENSP00000304782

UniGene: Hs.268700

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