CES3 Antibody

Code CSB-PA005260GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
CES3
Alternative Names
Carboxylesterase 3 antibody; CES 3 antibody; Ces3 antibody; ES3 antibody; EST3_HUMAN antibody; FLJ21736 antibody; Liver carboxylesterase 31 homolog antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human CES3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
Gene References into Functions
  1. This study provides the first evidence of functional compensation whereby increased expression of CES3 restores intracellular cholesteryl ester hydrolytic activity and free cholesterol efflux in CES1-deficient cells. PMID: 22700792
  2. Studies indicate that CES3 mRNA isoform expression in several tissues, particularly in colon, trachea and in brain. PMID: 20422440
  3. CES3 seems to have a lower catalytic efficiency than the other two CESs for selected substrates. PMID: 19508181
  4. pharmacogenomic characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes PMID: 18794728
Subcellular Location
Endoplasmic reticulum lumen.
Protein Families
Type-B carboxylesterase/lipase family
Tissue Specificity
Expressed in liver, colon and small intestine.
Database Links

HGNC: 1865

OMIM: 605279

KEGG: hsa:23491

STRING: 9606.ENSP00000304782

UniGene: Hs.268700

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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