CGNL1 Antibody

Datasheet

Code	CSB-PA005304GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q0VF96

Target Names

CGNL1

Alternative Names

Cgnl1 antibody; CGNL1_HUMAN antibody; Cingulin like 1 antibody; Cingulin-like protein 1 antibody; FLJ14957 antibody; JACOP antibody; Junction-associated coiled-coil protein antibody; KIAA1749 antibody; MGC138254 antibody; Paracingulin antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human CGNL1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons.

Gene References into Functions

demonstrate in a postnatal retinal vascular development model in mice that Cgnl1 function is crucial for sustaining neovascular growth and stability PMID: 29016873
Results indentify plausible candidates include non-recurrent deletions at the glutamate transporter gene SLC1A1, a CNV locus recently suggested to be involved in schizophrenia through linkage analysis, and duplications at 1p36.33 and CGNL1. PMID: 24163246
ZO-1 and PLEKHA7 are paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively PMID: 21454477
Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions PMID: 18653465
This paper studied the mouse JACOP protein and found that the JACOP protein has structural and functional similarities to cingulin. PMID: 15292197

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Involvement in disease

Aromatase excess syndrome (AEXS)

Subcellular Location

Cell junction, tight junction.

Protein Families

Cingulin family

Tissue Specificity

Smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus and subthalamic nucleus of adult brain.

Database Links

HGNC: 25931

OMIM: 139300

KEGG: hsa:84952

STRING: 9606.ENSP00000281282

UniGene: Hs.148989

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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