CHCHD3 Antibody

Datasheet

Code	CSB-PA873679ESR1HU
Size	US$166
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Image	Western blot All lanes: CHCHD3 antibody at 0.56µg/ml Lane 1: Mouse heart tissue Lane 2: Mouse kidney tissue Lane 3: Mouse lung tissue Lane 4: A549 whole cell lysate Lane 5: HepG2 whole cell lysate Lane 6: 293T whole cell lysate Lane 7: A431 whole cell lysate Lane 8: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 26 kDa Observed band size: 26 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA873679ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA873679ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CHCHD3 Polyclonal antibody

Uniprot No.

Q9NX63

Target Names

CHCHD3

Alternative Names

CHCH3_HUMAN antibody; CHCHD 3 antibody; Chchd3 antibody; Coiled coil helix coiled coil helix domain containing 3 antibody; Coiled coil helix coiled coil helix domain containing protein 3 mitochondrial antibody; Coiled-coil-helix-coiled-coil-helix domain-containing protein 3 antibody; FLJ20420 antibody; MINOS3 antibody; mitochondrial antibody; Mitochondrial inner membrane organizing system 3 antibody; PPP1R22 antibody; Protein phosphatase 1 regulatory subunit 22 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human MICOS complex subunit MIC19 protein (1-227AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.

Gene References into Functions

Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50. PMID: 28808085
The findings suggest that Mic19 is a redox-dependent regulator of mitochondrial contact site and crista organizing system complex function. PMID: 26416881
both the myristoylation and the CHCH domain are essential for the import and mitochondrial localization of ChChd3. Once imported, ChChd3 binds to Mia40 for further folding and assembly into macromolecular complexes. PMID: 23019327
ChChd3 is a scaffolding protein that stabilizes protein complexes involved in maintaining crista architecture and protein import and is thus essential for maintaining mitochondrial structure and function. PMID: 21081504
mitofilin helps regulate mitochondrial morphology and at least four of the associated proteins (metaxins 1 and 2, SAM50 and CHCHD3) have been implicated in protein import PMID: 17624330

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Subcellular Location

Mitochondrion inner membrane; Lipid-anchor; Intermembrane side. Cytoplasm. Nucleus. Mitochondrion.

Protein Families

MICOS complex subunit Mic19 family, Metazoan Mic19 subfamily

Tissue Specificity

Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue.

Database Links

HGNC: 21906

OMIM: 613748

KEGG: hsa:54927

STRING: 9606.ENSP00000262570

UniGene: Hs.655010

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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