CHP2 Antibody

Code CSB-PA869859
Size US$297
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  • Western blot analysis of extracts from Jurkat cells, K562 cells and HT-29 cells, using CHP2 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CHP2 Polyclonal antibody
Uniprot No.
Target Names
CHP2
Alternative Names
CHP2 antibody; HCA520Calcineurin B homologous protein 2 antibody; Hepatocellular carcinoma-associated antigen 520 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from internal of HumanCHP2.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
Gene References into Functions
  1. CHP2 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
  2. chp2 expression in leukemia primary cells and leukemia cell lines is significantly increased. PMID: 18718049
  3. These findings suggest that CHP serves as an obligatory subunit that is required both for supporting the basic activity and regulating the pH-sensing of NHE1 via interactions between distinct parts of these proteins. PMID: 16710297
  4. overexpression of the CHP2 gene affects the biological behavior of ovarian cancer cell line OVCAR3 and is one of key mechanisms for ovarian carcinoma progression PMID: 17708351
Subcellular Location
Nucleus. Cytoplasm. Cell membrane.
Protein Families
Calcineurin regulatory subunit family, CHP subfamily
Tissue Specificity
Expressed in malignantly transformed cells but not detected in normal tissues.
Database Links

HGNC: 24927

KEGG: hsa:63928

STRING: 9606.ENSP00000300113

UniGene: Hs.178589

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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