CHRD Antibody

1. Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling. PMID: 26517884
2. C-terminal chordin domains play an important role in Bone morphogenetic protein regulation. PMID: 25157165
3. chordin silencing increased osteogenic differentiation without supplemented BMP-2. PMID: 23931154
4. results suggest that CHRD could participate in regulating BMP activity in normal ovarian surface epithelium physiology, and that its mis-expression in ovarian surface epithelium may facilitate cancer incidence and/or progression PMID: 16449796
5. Bone morphogenetic protein (BMP) chordin is produced endogenously during osteogenic differentiation of human mesenchymal stem cells (MSCs); blockade of bone morphogenetic inhibitor chordin increases the rate of osteogenic differentiation of MSCs in vitro. PMID: 18533030
6. Noggin and chordin were also expressed most intensely in areas of cartilage formation and there was no difference in their expression between the non-hypertrophic and hypertrophic chondrocytes. PMID: 19023570
7. there was no difference in the expression of the noggin and chordin between healing and nonhealing fractures PMID: 19058174
8. Alternatively spliced variants have different patterns of expression to influence BMP activity in varying physiolgical situations. PMID: 11472837

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HGNC: 1949

OMIM: 603475

KEGG: hsa:8646

STRING: 9606.ENSP00000204604

UniGene: Hs.166186