CIR1 Antibody

Code CSB-PA773051DSR1HU
Size US$166
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  • Western blot
    All lanes: TMOD1 antibody at 2.84μg/ml
    Lane 1: PC-3 whole cell lysate
    Lane 2: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 53, 24 kDa
    Observed band size: 53 kDa

  • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA773051DSR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA773051DSR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CIR1 Polyclonal antibody
Uniprot No.
Target Names
CIR1
Alternative Names
CIR1 antibody; CIRCorepressor interacting with RBPJ 1 antibody; CBF1-interacting corepressor antibody; Recepin antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Corepressor interacting with RBPJ 1 protein (1-160AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Gene References into Functions
  1. three SNPs (corepressor interacting with RBPJ 1 (CIR1) rs13009079T>C, ribonucleotide reductase M1 (RRM1) rs1465952T>C and solute carrier family 38, member 4 (SLC38A4) rs2429467C>T), may play a role in the pathogenesis of lung cancer PMID: 27587543
  2. identified as a PAP-1 binding protein and as a splicing factor PMID: 15652350
Subcellular Location
Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
Tissue Specificity
Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.
Database Links

HGNC: 24217

OMIM: 605228

KEGG: hsa:9541

STRING: 9606.ENSP00000339723

UniGene: Hs.632531

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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