CISD2 Antibody

1. CDGSH iron-sulfur domain-containing protein 2 (CISD2) Wolfram syndrome type 2 (WFS2) primary fibroblast cell lines showed consistent reduction in proliferation. PMID: 29239282
2. CISD2 haploinsufficiency disrupts calcium homeostasis, causing ER stress and subsequent nonalcoholic fatty liver disease and nonalcoholic steatohepatitis PMID: 29166610
3. CISD2 was increased in glioma samples and was associated with poor prognosis and aggressive tumor behavior. The miR449a/CISD2/beclin1mediated autophagy regulatory network contributed to the proliferation of glioma cells PMID: 28983596
4. CISD2 is down-regulated in gastric cancer, and its effects on the inhibition of cellular proliferation, metastatic ability, and increased chemotherapy sensitivity are mediated by antagonism to 5-FU-induced autophagy through the AKT/mTOR pathway. PMID: 28857517
5. The c.103 + 1G > A mutation resulted in the loss of functional CISD2 protein in the two Italian Wolfram syndrome type 2 patients. PMID: 29237418
6. CISD2 was up-regulated in laryngeal squamous cell carcinoma PMID: 27007153
7. CISD2 could be an independent prognostic factor for PC and suggested that the CISD2/Wnt/beta-catenin pathway contributed to the proliferation of PC and EMT PMID: 27983920
8. the patient that we describe in this report with the c.215A > G missense CISD2 variant had the classical features of Wolfram syndrome type 1. The c.215A > G (p.Asn72Ser) variant does not induce CISD2 RNA mis-splicing or a reduction in CISD2 protein levels. Thus, we report a novel missense homozygous CISD2 mutation in a patient with clinical features that differ from previously reported Wolfram syndrome 2 case reports. PMID: 28335035
9. CISD2 exerts anti-apoptotic and anti-inflammatory effects in neural cells; and (2) curcumin can attenuate the downregulation of CISD2 in SCI and LPS-treated astrocytes. PMID: 26387034
10. CISD2 protein may serve as a candidate prognostic marker and a novel therapeutic target for hepatocellular carcinoma (HCC) and play an important role in promoting proliferation and enhanced progression of HCC. PMID: 26722601
11. The findings suggested that CISD2 haplotype-tagging single nucleotide polymorphisms are not associated with Alzheimer's disease risk. PMID: 26154755
12. NAF-1 is a BCL-2-associated co-factor that targets BCL-2 for antagonism of the autophagy pathway at the endoplasmic reticulum. PMID: 20010695
13. NAF-1 as a previously unidentified cell target of anti-diabetes thiazolidinedione drugs. PMID: 23717386
14. provides the first structural information, to our knowledge, for future targeting of the NAF-1-Bcl-2 complex in the regulation of apoptosis/autophagy in cancer biology PMID: 24706857
15. High CISD2 expression was significantly associated with gastric cancer. PMID: 26565812
16. NAF-1 is a major player in the metabolic regulation of breast cancer cells. PMID: 26621032
17. A novel CISD2 mutation is associated with wolfram syndrome 2. PMID: 25371195
18. Studied the expression pattern and clinicopathological significance of CISD2 in patients with early-stage cervical cancer. PMID: 25134919
19. Data show that the protein levels of NAF-1 (CISD2) and mNT (CISD1) are elevated in human epithelial breast cancer cells. PMID: 23959881
20. CISD2 has a role in lifespan control and disease [review] PMID: 20649540
21. Novel mutation, new phenotypic variant with no diabetes insipidus, presence of peptic ulcer disease, platelet aggregation defect PMID: 14724730
22. A single missense mutation was identified in a novel, highly conserved zinc-finger gene, ZCD2, in three consanguineous families of Jordanian descent with Wolfram syndrome (WFS). PMID: 17846994
23. The authors show that Miner1 is a homodimer harboring two redox-active 2Fe-2S clusters, indicating for the first time an association of a redox-active FeS protein with Wolfram Syndrome 2. PMID: 19580816

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HGNC: 24212

OMIM: 604928

KEGG: hsa:493856

STRING: 9606.ENSP00000273986

UniGene: Hs.444955