CLDN23 Antibody

Code CSB-PA780406
Size US$299
Image
  • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-5: HUVEC cells, 293T cells, mouse bladder tissue, human placenta tissue, mouse kidney tissue, Primary antibody: CSB-PA780406(CLDN23 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
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Product Details

Uniprot No. Q96B33
Target Names CLDN23
Alternative Names
CLDN23; Claudin-23
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Fusion protein of Human CLDN23
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,WB
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Gene References into Functions
  1. The expression of claudin-11, -23 was remarkably downregulated in gastric cancer. PMID: 28350854
  2. The present study demonstrated an epigenetic link between the activity of the EZH2 methyltransferase at the CLDN23 locus and the expression of CLDN23 in CRC tissue. PMID: 25695204
  3. Down-regulation of CLDN23 is associated with colorectal cancer. PMID: 24222123
  4. characterization of CLDN23 gene, a candidate tumor suppressor gene implicated in intestinal-type gastric cancer PMID: 12736707
  5. Human CLDN23, showing 79.5% total-amino-acid identity with mouse Cldn23, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707

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Subcellular Location Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein Families Claudin family
Tissue Specificity Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor.
Database Links

HGNC: 17591

OMIM: 609203

KEGG: hsa:137075

STRING: 9606.ENSP00000428780

UniGene: Hs.183617

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