CLEC11A Antibody

1. Clec11a maintains the adult skeleton by promoting the differentiation of mesenchymal progenitors into mature osteoblasts. PMID: 27976999
2. Data show that asymptomatic patients with unstable plaques exhibited higher levels of endothelial microparticles (EMPs), CXCL9 chemokine and stem cell growth factor; lymphocyte secreted C-type lectin (SCGF-beta) compared to those with stable plaques. PMID: 26564003
3. level of expression correlates with pain response in subjects with intervertebral disc disorders PMID: 26440592
4. This is the first report of SCGF beta in heart failure patients. PMID: 23357302
5. These studies highlight a possible role of SCGFalpha in imatinib-induced changes of gastrointestinal stromal tumors structure, consistent with a therapeutic response. PMID: 21943129
6. The results presented here demonstrate that homozygous T at -539 in the SCGF promoter is associated with elevated SCGF production, enhanced erythropoiesis, and protection against severe malarial anemia. PMID: 19884328
7. SCGF is selectively produced by osseous and hematopoietic stromal cells, and can mediate their proliferative activity on primitive hematopoietic progenitor cells. PMID: 11920266
8. Results indicate that interleukin-4, together with recombinant human stem cell factor, can induce T cell maturation from cord blood progenitor cells, and that IL-4 increased the expression of FcepsilonRI on fetal liver mast cells. PMID: 14746805
9. Human vascular smooth muscle cells express stem cell factor(SCF) and its receptor, c-kit. SCF is released from its membrane-bound form via MMP-9. SCF/c-kit signaling may affect SMC function via an autocrine pathway. PMID: 15234225
10. phagocytosis of hemozoin promotes a decrease in SCGF gene products, which may contribute to reduced erythropoiesis in children with severe malarial anemia. PMID: 19528216

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HGNC: 10576

OMIM: 604713

KEGG: hsa:6320

STRING: 9606.ENSP00000250340

UniGene: Hs.512680