CNKSR3 Antibody

Datasheet

Code	CSB-PA757602LA01HU
Size	US$166
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Image	Immunofluorescent analysis of HepG2 cells using CSB-PA757602LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Western Blot Positive WB detected in: Mouse spleen tissue All lanes: CNKSR3 antibody at 2μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 62, 101, 93 kDa Observed band size: 62 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CNKSR3 Polyclonal antibody

Uniprot No.

Q6P9H4

Target Names

CNKSR3

Alternative Names

CNKSR3 antibody; MAGI1Connector enhancer of kinase suppressor of ras 3 antibody; Connector enhancer of KSR 3 antibody; CNK homolog protein 3 antibody; CNK3 antibody; CNKSR family member 3 antibody; Maguin-like protein antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Connector enhancer of kinase suppressor of ras 3 protein (301-555AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CNKSR3 Antibody (Product code: CSB-PA757602LA01HU) is Non-conjugated. For CNKSR3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA757602LB01HU	CNKSR3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA757602LC01HU	CNKSR3 Antibody, FITC conjugated
Biotin	CSB-PA757602LD01HU	CNKSR3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:2000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).

Gene References into Functions

SCAF8-CNKSR3 variant rs955333 was not associated with diabetic kidney disease but showed association with diabetic retinopathy in Chinese type 2 diabetes patients PMID: 28401168
Cox regression and Kaplan-Meier survival analysis identified that amplification of the CNKSR3 gene (log-rank, P = 0.022) with an associated increase in its protein expression (log-rank, P = 0.011) correlated with longer patient survival. PMID: 23357503
CNK3 is a molecular scaffold, which coordinates the assembly of a multiprotein ENaC-regulatory complex and hence plays a central role in Na(+) homeostasis. PMID: 22851176
two gene markers (CNKSR3 and SPTBN2) differentiate between aspirin-exacerbated respiratory disease and aspirin-tolerant asthma with a perfect discriminative power PMID: 22457146
CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration. PMID: 22085542
CNKSR3, a homologue of scaffold proteins involved in MAPK pathway regulation, is a direct target of MR and is required for the maintenance of transepithelial sodium transport in the kidney. PMID: 19567370

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Subcellular Location

Cytoplasm. Apical cell membrane; Peripheral membrane protein.

Protein Families

CNKSR family

Database Links

HGNC: 23034

OMIM: 617476

KEGG: hsa:154043

STRING: 9606.ENSP00000356182

UniGene: Hs.16064

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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