CNOT4 Antibody

Code CSB-PA020140
Size US$100
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Product Details

Uniprot No.
Target Names
CNOT4
Alternative Names
CCR4 NOT transcription complex subunit 4 antibody; CCR4-associated factor 4 antibody; CCR4-NOT transcription complex subunit 4 antibody; CLONE243 antibody; CNOT 4 antibody; Cnot4 antibody; CNOT4_HUMAN antibody; E3 ubiquitin-protein ligase CNOT4 antibody; NOT 4 antibody; NOT4 (negative regulator of transcription 4 yeast) homolog antibody; NOT4 antibody; NOT4H antibody; Potential transcriptional repressor NOT4Hp antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human CNOT4.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.
Gene References into Functions
  1. These results indicate that CNOT4 is a ubiquitin ligase of influenza A virus nucleoprotein, and ubiquitination of the nucleoprotein plays a positive role in viral RNA replication. PMID: 28536288
  2. CNOT4 controls the degradation of chromatin-unbound PAF1 via the 26S proteasome. PMID: 25933433
  3. Single nucleotide polymorphism in CNOT4 gene is associated with osteosarcoma susceptibility. PMID: 25663449
  4. Data show that Not4/CNOT4 is a novel positive regulator of the JAK/STAT pathway in Drosophila and in humans. PMID: 22159038
  5. Data show that binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective PMID: 15001359
  6. Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT4 binds CNOT1 in yeast two-hybrid assays. PMID: 19558367

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Subcellular Location
Cytoplasm. Nucleus.
Database Links

HGNC: 7880

OMIM: 604911

KEGG: hsa:4850

STRING: 9606.ENSP00000445508

UniGene: Hs.490224

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