CNTN1 Antibody

1. CNTN1 promotes growth, metastasis and invasion of Hs578T breast cancer cell line. PMID: 29673312
2. Proteolipid protein 1 and contactin 1 gene variation modulates interhemispheric integration PMID: 27864734
3. CNTN-1 promotes cisplatin resistance in human cisplatin-resistant lung adenocarcinoma through inducing the Epithelial-Mesenchymal Transition process by activating the PI3K/Akt signaling pathway. PMID: 28934754
4. CNTN1 is a new gene which can be regulated by RET/PTC3 (Ret proto-oncogene and Ret-activating protein ELE1) rearrangement gene and the protein level of CNTN1 is increasing in thyroid cancer. PMID: 26722434
5. Structurally, CASPR2 is highly glycosylated and has an overall compact architecture. CASPR2 associates with micromolar affinity with CNTN1 but, under the same conditions, it does not interact with any of the other members of the contactin family. PMID: 26721881
6. CNTN1 promotes prostate cancer progression. PMID: 26795349
7. High CNTN-1 expression is associated with metastasis in gastric cancer. PMID: 25952582
8. CNTN-1 is closely related with multidrug resistance of lung adenocarcinoma. PMID: 25960233
9. anti-CNTN1 IgG4 antibodies are associated with subacute onset of chronic inflammatory demyelinating polyneuropathy symptoms, sensory ataxia, and good response to corticosteroids. PMID: 25808373
10. under hypoxia conditions, elevated HIF-1alpha seems to up-regulate contactin-1 expression and by this activate RhoA and facilitate migration of cancer cells. PMID: 25916117
11. a completely novel function for F3/Contactin - modulator of neurogenesis PMID: 22360968
12. A high expression of CNTN1 was markedly associated with the regional lymph node metastasis of patients with oral squamous cell carcinoma. PMID: 22580838
13. The expression of CNTN-1 is upregulated in esophageal squamous cell carcinoma tissue and is related to stage and lymphatic invasion. Thus, it may be involved in the pathogenesis & progression of esophageal squamous cell carcinoma. PMID: 22581910
14. Data revealed that knockdown of VEGFR-3 with the shRNA lentiviral vector resulted in down-regulation of the downstream neural cell adhesion molecule contactin-1 (CNTN-1). PMID: 21805024
15. report the cocrystal structure of the carbonic anhydrase-like domain of PTPRZ bound to tandem Ig repeats of CNTN1 and binding assays to show that PTPRZ binds specifically to CNTN1 expressed at the surface of oligodendrocyte precursor cells PMID: 21969550
16. VEGF-C mediated biological function through transcription of CNTN-1, which is implicated in tumor invasion and metastasis. PMID: 21482472
17. F3 acts as a functional ligand for Notch during oligodendrocyte maturation. PMID: 14567914
18. The repulsive properties of contactin may be a key factor in glioma disaggregation, and may contribute to the diffuse infiltration pattern characteristic of glioma cells in human brain. PMID: 16078236
19. Contactin-1 is proposed to function importantly in the invasion and metastasis of lung adenocarcinoma cells via RhoA-mediated mechanisms. PMID: 16510572
20. Mutations in CNTN1, a neural adhesion molecule and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. PMID: 19026398

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HGNC: 2171

OMIM: 600016

KEGG: hsa:1272

STRING: 9606.ENSP00000325660

UniGene: Hs.143434