COASY Antibody

Code CSB-PA618754LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate
    All lanes: COASY antibody at 3.4μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 63, 66 kDa
    Observed band size: 63, 66 kDa

  • Immunofluorescent analysis of Hela cells using CSB-PA618754LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) COASY Polyclonal antibody
Uniprot No.
Target Names
COASY
Alternative Names
Bifunctional coenzyme A synthase antibody; Bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase antibody; CoA synthase antibody; COASY antibody; COASY_HUMAN antibody; Coenzyme A synthase antibody; Dephospho-CoA kinase antibody; Dephospho-CoA pyrophosphorylase antibody; Dephosphocoenzyme A kinase antibody; DPCK antibody; DPCOAK antibody; NBP antibody; Nucleotide binding protein antibody; Pantetheine-phosphate adenylyltransferase antibody; Phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase antibody; pOV 2 antibody; POV-2 antibody; POV2 antibody; PPAT antibody; UKR1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Bifunctional coenzyme A synthase protein (453-546AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The COASY Antibody (Product code: CSB-PA618754LA01HU) is Non-conjugated. For COASY Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA618754LB01HU COASY Antibody, HRP conjugated ELISA
FITC CSB-PA618754LC01HU COASY Antibody, FITC conjugated
Biotin CSB-PA618754LD01HU COASY Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
Gene References into Functions
  1. The recruitment of COASY inhibits CBP-mediated TPX2 acetylation, promoting TPX2 degradation for mitotic exit. PMID: 29531224
  2. The COASY protein contains a mitochondrial localization signal, a regulatory region and a domain for each of the two catalytic kinase domains: adenyl transferase and dephospho CoA PMID: 27021474
  3. DNA methylation levels in the COASY and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment. PMID: 27992572
  4. Exome sequencing revealed the presence of recessive missense mutations in COASY, encoding coenzyme A (CoA) synthase in neurodegeneration with brain iron accumulation PMID: 24360804
  5. EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies PMID: 22982864
  6. Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase). PMID: 11994049
  7. description of the existence of a novel CoA synthase isoform, which is the product of alternative splicing and possesses a 29aa extension at the N-terminus; termed it CoASy beta PMID: 16460672
  8. CoA synthase is involved in signaling events in the cell and forms a functional complex with p85alphaPI3K in vivo. PMID: 19482007

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Involvement in disease
Neurodegeneration with brain iron accumulation 6 (NBIA6)
Subcellular Location
Cytoplasm. Mitochondrion matrix.
Protein Families
Eukaryotic CoaD family
Tissue Specificity
Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liv
Database Links

HGNC: 29932

OMIM: 609855

KEGG: hsa:80347

STRING: 9606.ENSP00000464814

UniGene: Hs.296422

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