COL10A1 Antibody

Code CSB-PA005715ESR1HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
  • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA005715ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA005715ESR1HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) COL10A1 Polyclonal antibody
Uniprot No. Q03692
Target Names COL10A1
Alternative Names COAA1_HUMAN antibody; Col10a 1 antibody; COL10A1 antibody; Collagen alpha 1(X) chain antibody; Collagen alpha-1(X) chain antibody; Collagen type X alpha 1 (Schmid metaphyseal chondrodysplasia) antibody; Collagen type X alpha 1 antibody; Collagen X alpha 1 polypeptide antibody; CollagenX antibody; fa66d11 antibody; fb10c08 antibody; OTTHUMP00000040411 antibody; Procollagen type X alpha 1 antibody; Schmid metaphyseal chondrodysplasia antibody; wu:fa66d11 antibody; wu:fb10c08 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Collagen alpha-1(X) chain protein (521-680AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

(From Uniprot)
Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.
Gene References into Functions
  1. Plasma samples from lung cancer patients and healthy heavy-smokers controls were tested for levels of COL11A1 and COL10A1 (n = 57 each) and SPARC (n = 90 each). Higher plasma levels of COL10A1 were detected in patients (p PMID: 30227835
  2. All affected individuals are heterozygous for the missense mutation collagen type X alpha 1 chain (COL10A1) rs111033552. PMID: 29234170
  3. increased expression of stromal colXalpha1 and low TILs correlate with poor pathologic response in ER+/HER2+ breast tumors. Further studies are needed to confirm their predictive value and impact on long-term outcomes, and to determine whether this collagen exerts a protective effect on the cancer cells or simply reflects other factors within the tumor microenvironment PMID: 27090210
  4. a novel sequence variation involving an unusual mutational site of the COL10A1 gene can cause mild metaphyseal chondrodysplasia PMID: 25542771
  5. COL10A1 mutation 2005delC in a Chinese pedigree with Schmid type metaphyseal chondrodysplasia is close to the C-terminus of the protein sequence and may result in genetic heterogeneity of the Chinese population PMID: 25974987
  6. Concentration of serum collagen type X levels correlated with cartilage degradation in osteoarthritis patients. PMID: 25245039
  7. The results show that COL10A1 is a tumor biomarker upregulated in a wide variety of tumors including those of the breast, colon, bladder, stomach, esophagus, lung, testis, ovary and pancreas. PMID: 22894674
  8. Yiqi Huayu Bushen Recipe increased the expression of aggrecan, decreased the expression of type X collagen, and promoted cell proliferation in cells from degenerated human intervertebral discs. PMID: 22015197
  9. Genetic variation near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. PMID: 21665990
  10. MCDS is a rare genetic skeletal disorder caused by a collagen type X defect. Though much is known about the molecular pathology of the causative COL10A1 mutations, causal therapy of the disease is not yet available PMID: 21360259
  11. a frameshift mutation leading to elongation of the deduced alpha1(X) chain associated with Metaphyseal Chondrodysplasia type Schmid PMID: 21447328
  12. These results indicate that nitrogen-rich plasma polymerized surfaces inhibit COL10A1 expression via the suppression of COX-1. PMID: 20225218
  13. speculate that complete loss of mutant transcripts yields COL10A1 haploinsufficiency and late clinical presentation while incomplete loss of mutant transcripts yields dominant-negative effects with early clinical presentation PMID: 20872587
  14. The total expression of type X collagen in the concave side growth plates of the lower end vertebrae was higher than that in the same side growth plates of apex. PMID: 20073986
  15. methylation-based COL10A1 gene silencing is established in cartilage tissue and human articular chondrocytes during chondrogenesis. PMID: 18759285
  16. chains harboring Schmid metaphyseal chondrodysplasia NC1 domain mutations are selectively retained and degraded in stably transfected cells PMID: 11805116
  17. The crystal structure at 2.0 A resolution of the human collagen X NC1 domain reveals an intimate trimeric assembly strengthened by a buried cluster of calcium ions. PMID: 11839302
  18. The 4.6 kb promoter is able to drive specific expression of Col10a1 in hypertrophic cartilage. PMID: 15464363
  19. exposure of the NC1 thiol may trigger the recognition and degradation of mutant collagen X chains PMID: 15695517
  20. The effect of COL10A1 nonsense mutations in cartilage tissue has been examined in two patients, demonstrating that the mutant mRNA is completely removed by nonsense mediated mRNA decay PMID: 15880705
  21. retinoids stimulate collagen X transcription IN chondrocytes PMID: 16598786
  22. the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation PMID: 16806867
  23. Type X collagen was not detected in any of atehrosclerotic plaques investigated in crural arteries. PMID: 17335825
  24. Investigated a family affected with the Spahr type of metaphyseal chondrodysplasia. Sequencing of RMRP, and a haplotype analysis using highly informative markers around the COL10A1 excluded both genes from being pathogenic in this family. PMID: 18553549
  25. HY(hypertrophy) box is the core element responsive to RUNX-2 in human COL10A1 promoter PMID: 19116917

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Involvement in disease Schmid type metaphyseal chondrodysplasia (SMCD)
Subcellular Location Secreted, extracellular space, extracellular matrix
Database Links

HGNC: 2185

OMIM: 120110

KEGG: hsa:1300

STRING: 9606.ENSP00000243222

UniGene: Hs.520339


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