COMMD1 Antibody

1. Sp1 constitutively regulates the basal expression of the COMMD1 gene in human epithelial cell lines. PMID: 29336469
2. This study has thus revealed a novel nuclear complex of F-actin, DRR1 and COMMD1 that is involved in NF-kappaB degradation and cell cycle suppression in neuroblastoma cells. PMID: 28604741
3. these results identify COMMD1 and an E2F-metabolic pathway as key regulators of osteoclastogenic responses under pathological inflammatory conditions PMID: 28723554
4. The COMMD1 downregulation by miR-205 promotes tumor development by modulating a positive feedback loop that amplifies inflammatory- and stemness-associated properties of cancer cells. PMID: 26586569
5. COMMD1 plays a critical role in the termination of NF-kappaB activity and the control of pro-inflammatory and pro-labor mediators. PMID: 26733542
6. COMMD1 expression is associated with poor prognosis in diffuse large B-cell lymphoma PMID: 24625556
7. COMMD1 is identified as a novel regulator of misfolded protein aggregation. PMID: 24691167
8. COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and C16orf62. PMID: 25355947
9. COMMD1 is acetylated by p300 and that acetylation protects COMMD1 from XIAP-mediated proteosomal degradation PMID: 25074812
10. IkappaB-alpha protein was stabilized by COMMD1, which attenuated NF-kappaB signaling during Toll-like receptor ligand and tumor necrosis factor alpha treatment and enhanced HIV-1 latency in latently HIV-1-infected cells. PMID: 25520503
11. These data demonstrate the anti-inflammatory properties of COMMD1 in bronchial epithelial cells and open new therapeutic avenues in cystic fibrosis. PMID: 23892095
12. Placental COMMD1 expression is increased in women with severe preeclampsia compared to that found in women with normal pregnancies. PMID: 23364987
13. The role of COMMD1 in copper metabolism and it structure and function are discussed. PMID: 23677795
14. The results indicate a role for COMMD1 in the regulation of NKCC1 membrane expression and ubiquitination. PMID: 23515529
15. No major role can be attributed to Atox1 and COMMD in the pathophysiology or clinical variation of Wilson disease. PMID: 22677543
16. Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B. PMID: 22130675
17. These results suggest that COMMD1 downregulates deltaENaC activity by reducing deltaENaC surface expression through promoting internalization of surface deltaENaC to an intracellular recycling pool, possibly via enhanced ubiquitination. PMID: 21741370
18. Data show that COMMD1 interacts with CFTR. This interaction promotes CFTR cell surface expression as assessed by biotinylation experiments in heterologously expressing cells through regulation of CFTR ubiquitination. PMID: 21483833
19. We argue that COMMD1 participates in the normal disposition of copper within the hepatocyte and we speculate about that role. PMID: 21275100
20. COMMD1 as a novel protein regulating SOD1 activation and associate COMMD1 function with the production of free radicals. PMID: 20595380
21. report a single novel, putative mutation in COMMD1 in one Wilson disease (WD) patient with atypical features; absence of any other prospective mutations among 108 patients suggests that COMMD1 variants are not major contributors towards WD phenotypes PMID: 20550661
22. Elevated levels of sCLU promote prostate cancer cell survival by facilitating degradation of COMMD1 and I-kappaB, thereby activating the canonical NF-kappaB pathway. PMID: 20068069
23. COMMD1 has a role in conjunction with HSP90beta/HSP70 in the ubiquitin and O(2)-independent regulation of HIF-1alpha PMID: 19802386
24. These data identify a new role for COMMD1 in regulating the nuclear/nucleolar distribution of RelA PMID: 20048074
25. No mutations in the MURR1 gene, including the intron-exon boundaries, were identified in a total of 23 patients with non-Wilsonian hepatic copper toxicosis PMID: 12547404
26. findings reveal involvement of Murr1 in the defined pathway of hepatic biliary copper excretion, suggest a mechanism for Murr1 function in this process, and provide evidence in support of the proposed role of the MURR1 gene in hepatic copper toxicosis PMID: 12968035
27. MURR1 was detected in different tissues and cell lines; in cell lines it was found both in cytosol and membrane preparations; in some cells MURR1 was associated with a vesicular compartment diffusely localized throughout the cell PMID: 14568250
28. Murr1 is a novel regulator of delta ENaC PMID: 14645214
29. Murr1, a gene product known previously for its involvement in copper regulation, inhibits HIV-1 growth in unstimulated CD4+ T cells PMID: 14685242
30. XIAP functions through MUUR1 to regulate copper homeostasis. PMID: 14685266
31. 3 intronic base pair changes, 1 new sequence variation & 2 known polymorphisms were detected, including the GAT/GAC heterozygous state at Asn 164 in 24% of the patients. GAT/GAC heterozygosity at Asn 164 is associated with earlier onset of Wilson disease. PMID: 15205742
32. MURR1/COMMD1 functions in the nucleus by affecting the association of NF-kappaB with chromatin PMID: 15799966
33. COMMD1 is not a significant contributor to Wilson-like copper storage disorders in humans. PMID: 16283886
34. These data support the significance of COMMD protein-protein interactions and provide new mechanistic insight into the function of this protein family in NF-kappaB signalling. PMID: 16573520
35. The solution structure of the N-terminal domain of COMMD1 (N-COMMD1, residues 1-108), is presented. PMID: 17097678
36. COMMD1 accelerates the ubiquitination and degradation of NF-kappaB subunits through its interaction with a multimeric ubiquitin ligase containing Elongins B and C, Cul2 and SOCS1 (ECS(SOCS1)). PMID: 17183367
37. COMMD1 specifically binds copper as Cu(II) in 1:1 stoichiometry & does not bind other divalent metals. Fluorescence studies of single point mutants of the full-length protein revealed the involvement of M110 in addition to H134 in direct Cu(II) binding. PMID: 17309234
38. Implicate COMMD1 in the pathogenesis of Wilson's disease and indicate that COMMD1 exerts its regulatory role in copper homeostasis through the regulation of ATP7B stability. PMID: 17919502
39. the ability to promote Lys(63)-mediated polyubiquitination of COMMD1 is a novel property of ARF independent of p53 PMID: 18305112
40. COMMD1 expression is controlled primarily by protein ubiquitination PMID: 18795889
41. COMMD1 is a scaffold protein in a distinct sub-compartment of endocytic pathway and offer first clues to its role as a regulator of structurally unrelated membrane transporters. PMID: 18940794
42. Data suggest that translocation of ATP7B takes place independently of Rab7-regulated endosomal traffic, and that Murr1 plays a role in a later step of the copper excretion pathway but is not involved in the translocation of the Wilson disease protein. PMID: 18974300

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HGNC: 23024

OMIM: 607238

KEGG: hsa:150684

STRING: 9606.ENSP00000308236

UniGene: Hs.468702