COQ3 Antibody

Datasheet
Code CSB-PA127898
Size US$299
Uniprot No. Q9NZJ6
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA127898(EIF2AK3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA127898(EIF2AK3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HT29 cells, Primary antibody: CSB-PA127898(EIF2AK3 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
Immunogen Fusion protein of Human EIF2AK3
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC;ELISA:1:2000-1:5000,WB:1:200-1:1000,IHC:1:50-1:200
Relevance The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias eukaryotic translation initiation factor 2-alpha kinase 3
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Target Names COQ3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
Subcellular Location Mitochondrion inner membrane, Peripheral membrane protein, Matrix side
Protein Families Class I-like SAM-binding methyltransferase superfamily, UbiG/COQ3 family
Database Links

HGNC: 18175

OMIM: 605196

KEGG: hsa:51805

STRING: 9606.ENSP00000254759

UniGene: Hs.713623

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