CPLX1 Antibody

1. data define CPLX1 as a PD risk factor and provide functional insights into the role and regulation of blood SNCA levels. The new blood biomarkers of PARK4 in this Turkish family might become useful for PD prediction PMID: 28108469
2. Homozygous CPLX1 variants were identified in three patients with severe infantile myoclonic epilepsy and ID. PMID: 28422131
3. This study demonstrated that complexin-I influence cognitive function in early and late stages of Alzheimer's disease. PMID: 27866231
4. Study showed for the first time that neuro-Behcet's disease and Behcet's disease patients are inclined to display the GG genotype of the CPLX1 rs936551 polymorphism and to exhibit increased CPLX1 expression levels PMID: 26577184
5. Collectively these results demonstrate that CPX-1 is a secreted collagen-binding glycoprotein and provide a foundation for future studies investigating the function of CPX-1. PMID: 26603934
6. Studies indicate the role of the small regulatory factor complexin in Ca(2+)-dependent vesicle fusion and exocytosis. PMID: 26245303
7. Data support the the trans insertion model for complexin clamping. PMID: 25831964
8. Together with synaptotagmin 1, complexin synchronizes and stimulates rapid fusion of accumulated docked vesicles in response to physiological Ca(2+) concentrations. PMID: 22705946
9. The crystal structure of complexin bound to a prefusion SNAREpin mimetic shows that the accessory helix extends away from the SNAREpin in an 'open' conformation, binding another SNAREpin and inhibiting its assembly, to clamp fusion. PMID: 21785412
10. The 'central helix' of complexin is anchored to one SNARE complex, while its 'accessory helix' extends away at ~45 degrees and bridges to a second complex, occupying the vacant v-SNARE binding site to inhibit fusion. PMID: 21785414
11. description of what may represent a basic principle of the coupling mechanism in SNARE dependent exocytosis: a reversible clamping protein, complexin, that can freeze the SNAREpin, an assembled fusion-competent intermediate en route to fusion PMID: 16794037
12. CX1 level increased progressively across development PMID: 18240322

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HGNC: 2309

OMIM: 605032

KEGG: hsa:10815

STRING: 9606.ENSP00000305613

UniGene: Hs.478930