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CPSF2 Antibody

Datasheet
Code CSB-PA005916GA01HU
Size $600
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Product Details

Uniprot No.
Q9P2I0
Target Names
CPSF2
Alternative Names
Cleavage and polyadenylation specific factor 2 antibody; cleavage and polyadenylation specific factor 2; 100kDa antibody; Cleavage and polyadenylation specificity factor 100 kDa subunit antibody; Cleavage and polyadenylation specificity factor subunit 2 antibody; CPSF 100 kDa subunit antibody; CPSF 2 antibody; CPSF100 antibody; Cpsf2 antibody; CPSF2_HUMAN antibody; KIAA1367 antibody; zgc:92484 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human CPSF2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing.
Gene References into Functions
  1. CPSF2 may have a role in Papillary Thyroid Carcinoma PMID: 26148673
  2. CPSF2 and SYMPK, are RBFOX2 cofactors for both inclusion and exclusion of internal exons. PMID: 25921069
  3. Decreased CPSF2 expression is associated with increased cellular invasion and cancer stem cell population, and more aggressive disease in papillary thyroid cancer. PMID: 24654752
  4. Conserved residues in CPSF2 and CPSF-73 are required for assembly of the endonuclease activity that cleaves histone pre-mRNAs. PMID: 18688255
Subcellular Location
Nucleus.
Protein Families
Metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, CPSF2/YSH1 subfamily
Database Links

HGNC: 2325

OMIM: 606028

KEGG: hsa:53981

STRING: 9606.ENSP00000298875

UniGene: Hs.657632

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