CPSF6 Antibody

1. The authors demonstrate that CFIm functions as an enhancer-dependent activator of mRNA 3' processing. CFIm regulates global alternative polyadenylation by specifically binding and activating enhancer-containing poly(A) sites. PMID: 29276085
2. High CPSF6 expression is associated with HIV infections. PMID: 29643241
3. we found CPSF6 and all core paraspeckles proteins to be overexpressed in human breast cancer cases and their expression to correlate with poor patient outcomes. PMID: 28673861
4. Studies suggest that binding of cleavage factor Im (CFIm) may be one of the earliest steps in promoting formation of an active cleavage complex. PMID: 27528751
5. CPSF6 binding to its docking site in HIV-1 capsid leads to the recruitment of CFIm tetramer, suggesting that CFIm mediates CPSF6 function(s) in integration site targeting. PMID: 26994143
6. integration targeting proceeds via two distinct mechanisms: capsid-CPSF6 binding directs HIV-1 to actively transcribed euchromatin, where the integrase-LEDGF/p75 interaction drives integration into gene bodies. PMID: 26858452
7. Structural basis of HIV-1 capsid recognition by PF74 and CPSF6. PMID: 25518861
8. study uncovers two opposing CA-dependent functions of CPSF6 in HIV-1 replication in vivo; however, the benefit for binding CPSF6 appears to outweigh the cost, providing support for a vital function of CPSF6 during HIV-1 replication in vivo PMID: 24415937
9. CPSF6 binds specifically to a novel proteinprotein interface on the N-terminal domain of HIV-1 capsid protein (CA). PMID: 22956906
10. These results suggested that inhibition of HIV-1 by TNPO3-depleted cells requires CPSF6. PMID: 23622145
11. Loss-of-function of CFIm68 and CFIm25 leads to a transcriptome-wide increase in the use of proximal polyadenylation sites in HEK293 cells. PMID: 23187700
12. TNPO3 promotes HIV-1 infectivity indirectly, by shifting the CA-binding protein CPSF6 to the nucleus, thus preventing the excessive HIV-1 CA stability that would otherwise result from cytoplasmic accumulation of CPSF6. PMID: 23414560
13. A carboxy-terminally truncated human CPSF6 lacking residues encoded by exon 6 inhibits HIV-1 cDNA synthesis and promotes capsid disassembly. PMID: 23658440
14. Knockdown of CF I(m)68 induced a systematic use of proximal polyadenylation sites, indicating that changes in relative abundance of a single 3' end processing factor can modulate the length of 3' untranslated regions across the transcriptome. PMID: 22813749
15. A 9-residue stretch of hydrophobic amino acids in CPSF6 restricts HIV-1 infection through an interaction with capsid. PMID: 22301135
16. The study reports the crystal structure of human cleavage factor I(m), comprising cleavage factor I(m)25 and the RNA recognition motif domain of cleavage factor I(m)68 kDa (CF I(m)68RRM). PMID: 21483454
17. Crystal structure of CFIm25-CFIm68 RRM heterotetramer illustrated that CFIm25 homodimer is clamped by two CFIm68 monomers on each side of the dimer interface PMID: 21295486
18. Structure of a CFI(m)25/CFI(m)68 RRM heterotetramer and biochemical data indicated that CFIm25 specifically recognized two UGUA elements, CFIm68 facilitates looping of the intervening RNA. CFIm-mediated RNA looping may regulate alternative polyadenylation PMID: 21295486
19. HIV-1 harboring the N74D mutation in capsid protein fails to interact with CPSF6 and evades the nuclear import restriction. PMID: 20227665
20. These results reveal a novel function for the pre-mRNA 3' end processing factor CF I(m)68 in mRNA export. PMID: 19864460
21. Data show that cleavage factor I(m) can stimulate both cleavage and poly(adenine) addition, and can act to suppress poly(A) site cleavage in a sequence-dependent manner. PMID: 14690600
22. a direct role of the U2AF 65/CF I(m) 59 interaction in the functional coordination of splicing and 3' end processing. PMID: 17024186
23. CF Im68 subnuclear distribution and mobility PMID: 17267687
24. Key paper demonstrating mechanism of CF Im binding to CPSF. Also challenges the long standing perception of mammalian mRNA 3'-end processing that insists that mammalian poly (A) sites are determined by two sequence elements alone. PMID: 15937220
25. Elevated levels of human cleavage factor Im suppressed cleavage at the primary poly(A) site of the pre-mRNA encoding the 68 kDa subunit of CFI(m). PMID: 14690600

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HGNC: 13871

OMIM: 604979

KEGG: hsa:11052

STRING: 9606.ENSP00000391774

UniGene: Hs.369606