CRAT Antibody

Datasheet

Code	CSB-PA14169A0Rb
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA14169A0Rb at dilution of 1:100 Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA14169A0Rb at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CRAT Polyclonal antibody

Uniprot No.

P43155

Target Names

CRAT

Alternative Names

CACP_HUMAN antibody; Carnitine acetylase antibody; Carnitine acetyltransferase antibody; Carnitine O acetyltransferase antibody; Carnitine O-acetyltransferase antibody; CAT antibody; CAT1 antibody; CrAT antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Carnitine O-acetyltransferase protein (181-346AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CRAT Antibody (Product code: CSB-PA14169A0Rb) is Non-conjugated. For CRAT Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA14169B0Rb	CRAT Antibody, HRP conjugated	ELISA
FITC	CSB-PA14169C0Rb	CRAT Antibody, FITC conjugated
Biotin	CSB-PA14169D0Rb	CRAT Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates.

Gene References into Functions

CrAT turned out to be active towards some but not all the BCAAO intermediates tested and no activity was found with dicarboxylic acyl-CoA esters. PMID: 23485643
the purification, crystallization and preliminary X-ray crystallographic studies of human carnitine acetyltransferase are reported PMID: 12077440
The structure and reactions of this enzyme are examined. PMID: 12562770
structure of a binary complex of human peroxisomal carnitine acetyltransferase and the substrate l-carnitine, refined to a resolution of 1.8; site-directed mutagenesis and kinetic characterization PMID: 15099582
Data show that CrAT overexpression in primary human skeletal myocytes increased glucose uptake and attenuated lipid-induced suppression of glucose oxidation. PMID: 19553674
Human CPT1A, CPT1B, CPT2, CROT and CRAT are known to encode active carnitine acyltransferases. Earlier pfam annotations refer to the non-existing compound CARNITATE. In 2000 this has been changed to CARNITINE. PMID: 11001805

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Subcellular Location

Endoplasmic reticulum. Peroxisome. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.; [Isoform 1]: Mitochondrion.; [Isoform 2]: Peroxisome.

Protein Families

Carnitine/choline acetyltransferase family

Tissue Specificity

Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney.

Database Links

HGNC: 2342

OMIM: 600184

STRING: 9606.ENSP00000315013

UniGene: Hs.12068

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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