CRLS1 Antibody

1. Knockdown of human CRLS1 leads to a cardiolipin decrease, phosphatidylglycerol accumulation and mitochondrial elongation. PMID: 29251771
2. transgenic expression of cardiolipin synthase attenuated maladaptive cardiolipin remodeling and bioenergetic inefficiency in myocardium rendered diabetic by streptozotocin treatment. PMID: 22584571
3. CLS mRNA levels cannot be correlated with CLS enzyme activity nor CL content in the LPS model of inflammation. PMID: 20652826
4. A human candidate gene/cDNA for cardiolipin synthase, C20orf155, was identified. PMID: 16678169
5. hCLS1 protein was localized to the mitochondria when transiently expressed in COS-7 cells PMID: 16716149
6. We describe here a human gene for CLS and its analysis via RNAi knockdown on apoptotic progression. PMID: 16888643
7. anti-cardiolipin antibody positivity is an independent predictor of chronic renal failure PMID: 19048414
8. Patients with solid and non-solid malignancies display anticardiolipin antibodies associated with increased rate of thrombosis PMID: 19048416
9. presence of cardiolipin autoantibodies is criteria for diagnostics of antiphospholipid syndrome PMID: 19052923
10. associated with Libman-Sacks endocarditis, cardiac manifestation of SLE PMID: 19089657
11. antibodies occur frequently in viral infections, particularly, in HIV but not in bacterial infections PMID: 19089659

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HGNC: 16148

OMIM: 608188

KEGG: hsa:54675

STRING: 9606.ENSP00000368140

UniGene: Hs.743956