CRTAC1 Antibody

Code CSB-PA005997LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: 293 whole cell lysate, A549 whole cell lysate
    All lanes: CRTAC1 antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 72, 71, 69 kDa
    Observed band size: 72 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CRTAC1 Polyclonal antibody
Uniprot No.
Target Names
CRTAC1
Alternative Names
68 kDa chondrocyte expressed protein antibody; 68 kDa chondrocyte-expressed protein antibody; Acidic secreted protein in cartilage antibody; ASPIC antibody; ASPIC1 antibody; Cartilage acidic protein 1 antibody; Cartilage acidic protein 1 precursor antibody; CEP 68 antibody; CEP-68 antibody; CEP68 antibody; Chondrocyte expressed protein 68 kDa CEP 68 antibody; CRAC1_HUMAN antibody; CRTAC1 antibody; Protein CRTAC1-B antibody; W307 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Cartilage acidic protein 1 protein (309-661AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CRTAC1 Antibody (Product code: CSB-PA005997LA01HU) is Non-conjugated. For CRTAC1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA005997LB01HU CRTAC1 Antibody, HRP conjugated ELISA
FITC CSB-PA005997LC01HU CRTAC1 Antibody, FITC conjugated
Biotin CSB-PA005997LD01HU CRTAC1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. Confirm the increase of CRTAC1 in cartilage biopsies from OA patients undergoing joint replacement by real-time PCR and immunohistochemistry. Furthermore, we report that proinflammatory cytokines interleukin-1beta and tumor necrosis factor alpha upregulate CRTAC1 expression in primary articular chondrocytes and synovial fibroblasts. PMID: 27415616
  2. It was shown for the first time the propensity of CRTAC1 to form amyloid-like structures, and it was hypothesized that the aggregating property of CRTAC1 may be related to its disease-association. PMID: 27862299
  3. These results provided new insights into the mechanism of cataract development, and demonstrated that CRTAC1 could be a potentially novel target for cataract treatment. PMID: 27855397
  4. CRTAC1 acquired an alternate last exon from the tail-to-tail oriented neighbouring gene in humans resulting in the glycosylated isoform CRTAC1-A which represents a new extracellular matrix molecule of articular cartilage. PMID: 17074475
  5. in bone fracture patients, 12 proteins were related to bone/cartilage metabolism, including: TGF-beta induced protein IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein and TGF-beta receptor III. PMID: 17602227

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Subcellular Location
Secreted, extracellular space, extracellular matrix.
Tissue Specificity
Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondrocytes and lung, and
Database Links

HGNC: 14882

OMIM: 606276

KEGG: hsa:55118

STRING: 9606.ENSP00000359629

UniGene: Hs.500736

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