CRTAC1 Antibody

Datasheet

Code	CSB-PA005997LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: 293 whole cell lysate, A549 whole cell lysate All lanes: CRTAC1 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 72, 71, 69 kDa Observed band size: 72 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CRTAC1 Polyclonal antibody

Uniprot No.

Q9NQ79

Target Names

CRTAC1

Alternative Names

68 kDa chondrocyte expressed protein antibody; 68 kDa chondrocyte-expressed protein antibody; Acidic secreted protein in cartilage antibody; ASPIC antibody; ASPIC1 antibody; Cartilage acidic protein 1 antibody; Cartilage acidic protein 1 precursor antibody; CEP 68 antibody; CEP-68 antibody; CEP68 antibody; Chondrocyte expressed protein 68 kDa CEP 68 antibody; CRAC1_HUMAN antibody; CRTAC1 antibody; Protein CRTAC1-B antibody; W307 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cartilage acidic protein 1 protein (309-661AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CRTAC1 Antibody (Product code: CSB-PA005997LA01HU) is Non-conjugated. For CRTAC1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA005997LB01HU	CRTAC1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA005997LC01HU	CRTAC1 Antibody, FITC conjugated
Biotin	CSB-PA005997LD01HU	CRTAC1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Gene References into Functions

Confirm the increase of CRTAC1 in cartilage biopsies from OA patients undergoing joint replacement by real-time PCR and immunohistochemistry. Furthermore, we report that proinflammatory cytokines interleukin-1beta and tumor necrosis factor alpha upregulate CRTAC1 expression in primary articular chondrocytes and synovial fibroblasts. PMID: 27415616
It was shown for the first time the propensity of CRTAC1 to form amyloid-like structures, and it was hypothesized that the aggregating property of CRTAC1 may be related to its disease-association. PMID: 27862299
These results provided new insights into the mechanism of cataract development, and demonstrated that CRTAC1 could be a potentially novel target for cataract treatment. PMID: 27855397
CRTAC1 acquired an alternate last exon from the tail-to-tail oriented neighbouring gene in humans resulting in the glycosylated isoform CRTAC1-A which represents a new extracellular matrix molecule of articular cartilage. PMID: 17074475
in bone fracture patients, 12 proteins were related to bone/cartilage metabolism, including: TGF-beta induced protein IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein and TGF-beta receptor III. PMID: 17602227

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Subcellular Location

Secreted, extracellular space, extracellular matrix.

Tissue Specificity

Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondrocytes and lung, and

Database Links

HGNC: 14882

OMIM: 606276

KEGG: hsa:55118

STRING: 9606.ENSP00000359629

UniGene: Hs.500736

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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