CRYAA Antibody, Biotin conjugated

Code CSB-PA006007LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CRYAA Polyclonal antibody
Uniprot No.
Target Names
CRYAA
Alternative Names
Acry 1 antibody; Alpha crystallin A chain antibody; Alpha-crystallin A chain antibody; CRYA 1 antibody; CRYA1 antibody; CRYAA antibody; CRYAA_HUMAN antibody; Crystallin alpha 1 antibody; Crystallin alpha A antibody; Heat shock protein beta 4 antibody; Heat shock protein beta-4 antibody; HSPB 4 antibody; HspB4 antibody; short form antibody; Zonular Central Nuclear Cataract antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Alpha-crystallin A chain protein (98-173AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Contributes to the transparency and refractive index of the lens. In its oxidized form (absence of intramolecular disulfide bond), acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
Gene References into Functions
  1. CRISPR/Cas9-mediated mutation of the alphaA-crystallin gene in rabbits recapitulates phenotypes of congenital cataracts, microphthalmia, obscurity, and early atrophy of the lens, and failed differentiation of lens fibers. PMID: 28475701
Involvement in disease
Cataract 9, multiple types (CTRCT9)
Subcellular Location
Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Protein Families
Small heat shock protein (HSP20) family
Tissue Specificity
Expressed in the eye lens (at protein level).
Database Links

HGNC: 2388

OMIM: 123580

KEGG: hsa:102724652

STRING: 9606.ENSP00000291554

UniGene: Hs.184085

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