CTAGE5 Antibody

1. TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats. PMID: 27551091
2. In this study, we identified specific and critical residues in the Sec12-binding region of cTAGE5 (E75A K76A, K89A, and S97A) and confirmed that cTAGE5-mediated Sec12 accumulation at ER exit sites is required for collagen VII secretion. PMID: 27170179
3. Data indicate that MIA2 represents a potential novel acute phase protein and MIA2 expression responds to liver damage in chronic liver diseases. PMID: 12586826
4. The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma. PMID: 17881540
5. population and bioinformatic analysis of MGEA6 P521A variation as a risk factor for Fahr's disease; genetic screen data show this mutation is very rare; bioinformatics analysis provided conflicting findings PMID: 20838928
6. cTAGE5 forms a complex with TANGO1 (MIA3), a previously characterized cargo receptor for collagen VII PMID: 21525241
7. HBx activates hepatoma cell growth and proliferation through repression of the potential tumor suppressor MIA2. PMID: 22120627
8. 22 members of an Iranian family with basal ganglia calfication as well as 100 controls were genotyped for the C>G P521A variant of CTAGE5, but none were found. PMID: 23054591
9. Findings suggest that the roles of MIA2 might be based on the variety of the integrins and the subtypes of mitogen-activated protein kinase in oral carcinoma. PMID: 23511560
10. Sec12 recruitment to endoplasmic reticulum exit sites is organized by its direct interaction with cTAGE5, a previously characterized collagen cargo receptor component, which functions together with TANGO1 at endoplasmic reticulum exit sites. PMID: 25202031
11. These findings define an interaction between the common MIA2(I141M) variant and the ER stress/UPR system and specify a subgroup of PDAC patients who are more likely to benefit from adjuvant chemotherapy. PMID: 25657029

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HGNC: 7057

OMIM: 602132

STRING: 9606.ENSP00000280083

UniGene: Hs.287694