CYFIP1 Antibody

Datasheet

Code	CSB-PA748722LA01HU
Size	US$166
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Image	Immunofluorescence staining of A549 cells with CSB-PA748722LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CYFIP1 Polyclonal antibody

Uniprot No.

Q7L576

Target Names

CYFIP1

Alternative Names

CY antibody; CYFIP 1 antibody; CYFIP1 antibody; CYFP1_HUMAN antibody; Cytoplasmic FMR1 interacting protein 1 antibody; Cytoplasmic FMR1-interacting protein 1 antibody; FLJ45151 antibody; KIAA0068 antibody; p140sra 1 antibody; p140sra-1 antibody; P140SRA1 antibody; Selective hybridizing clone antibody; SHYC antibody; Specifically Rac1 associated protein 1 antibody; Specifically Rac1-associated protein 1 antibody; SRA 1 antibody; Sra-1 antibody; SRA1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cytoplasmic FMR1-interacting protein 1 protein (320-449AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CYFIP1 Antibody (Product code: CSB-PA748722LA01HU) is Non-conjugated. For CYFIP1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA748722LB01HU	CYFIP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA748722LC01HU	CYFIP1 Antibody, FITC conjugated
Biotin	CSB-PA748722LD01HU	CYFIP1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. May act as an invasion suppressor in cancers.

Gene References into Functions

CYFIP1 gene expression was upregulated in the blood of epileptic patients. PMID: 29992499
The studies suggest that MNK-eiF4E axis controls the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, CYFIP1. (Review) PMID: 27527252
rs4778298, a common variant at CYFIP1 is associated with inter-individual variation in surface area across the left supramarginal gyrus. PMID: 27351196
Both mRNA and protein expression levels of Cyfip1 were significantly lower in ALL patients. PMID: 26779626
Reduced CYFIP1 in human neural progenitors results in dysregulation of schizophrenia and epilepsy gene networks. PMID: 26824476
Hippocampal synapses with reduced Cyfip1 are larger and release neurotransmitter more rapidly. PMID: 26843638
Data confirm that CYFIP1 is upregulated in transformed lymphoblastoid cell lines and demonstrate its upregulation in the post-mortem brain from 15q11-13 duplication patients for the first time PMID: 25311365
This study confirmed that CYFIP2 were altered in postsynaptic density in patient with schizophrenia. PMID: 25048004
haploinsufficiency causes cell polarity defects via WAVE complex destabilization; genetic polymorphism is associated with schizophrenia PMID: 24996170
An imbalance of specific isoforms of CYFIP1, an FMRP interaction partner, and CAMK4, a transcriptional regulator of the FMRP gene, modulates risk for autism spectrum disorders. PMID: 24442360
Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the trans-golgi network. PMID: 20228810
located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes PMID: 14508708
CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation PMID: 16260607
quantitated mRNA levels of NIPA2, NIPA2,l CYFIP1, and GCP5 in Prader-Willi syndrome and correlated levels with psychological and behavior scales PMID: 16982806
Study found that Cyfip1, a subunit of the WAVE complex, which regulates cytoskeletal dynamics, is commonly deleted in human epithelial cancers. PMID: 19524508

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Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, synapse, synaptosome.

Protein Families

CYFIP family

Database Links

HGNC: 13759

OMIM: 606322

KEGG: hsa:23191

STRING: 9606.ENSP00000324549

UniGene: Hs.26704

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Regulation of actin cytoskeleton

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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