CYP4F22 Antibody

Datasheet

Code	CSB-PA740654LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HEK293 whole cell lysate, Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate All lanes: CYP4F22 antibody at 3.2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 62 kDa Observed band size: 62 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CYP4F22 Polyclonal antibody

Uniprot No.

Q6NT55

Target Names

CYP4F22

Alternative Names

CYP4F22Cytochrome P450 4F22 antibody; EC 1.14.14.- antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cytochrome P450 4F22 protein (413-507AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CYP4F22 Antibody (Product code: CSB-PA740654LA01HU) is Non-conjugated. For CYP4F22 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA740654LB01HU	CYP4F22 Antibody, HRP conjugated	ELISA
FITC	CSB-PA740654LC01HU	CYP4F22 Antibody, FITC conjugated
Biotin	CSB-PA740654LD01HU	CYP4F22 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

A cytochrome P450 monooxygenase involved in epidermal ceramide biosynthesis. Hydroxylates the terminal carbon (omega-hydroxylation) of ultra-long-chain fatty acyls (C28-C36) prior to ceramide synthesis. Contributes to the synthesis of three classes of omega-hydroxy-ultra-long chain fatty acylceramides having sphingosine, 6-hydroxysphingosine and phytosphingosine bases, all major lipid components that underlie the permeability barrier of the stratum corneum. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).

Gene References into Functions

patients carrying one or two truncating CYP4F22 mutations affecting the SBRs tend to develop collodion membrane at birth PMID: 27735052
We report two cases of Congenital Ichthyosiform Erythroderma showing homozygous mutations in the gene CYP4F22. PMID: 26646773
description of CYP4F22 mutations from a Japanese collodion baby with lamellar ichthyosis [case report] PMID: 23871423
Letter: CYP4F22 is highly expressed at the site and timing of onset of keratinization during skin development. PMID: 22209317
REVIEW: genetic analyses have identified a wide spectrum of mutations in the CYP4V2gene from patients suffering from Bietti's crystalline corneoretinal dystrophy, and mutations in theCYP4F22 gene have been linked to lamellar ichthyosis PMID: 21540472

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Involvement in disease

Ichthyosis, congenital, autosomal recessive 5 (ARCI5)

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein.

Protein Families

Cytochrome P450 family

Database Links

HGNC: 26820

OMIM: 604777

KEGG: hsa:126410

STRING: 9606.ENSP00000269703

UniGene: Hs.156452

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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Address

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