CYTH1 Antibody

1. computational study suggests that although curcumin to some extent binds with Tp receptor, yet the inhibition of Arf6GDP to Arf6GTP conversion appeared to be an important mechanism by which curcumin inhibits U46619-induced increase in PLD activity in PASMCs. PMID: 28780751
2. CYTH1 is a novel major regulator of adhesion and engraftment in human hematopoietic stem and progenitor cells through mechanisms that, at least in part, involve the activation of integrins. PMID: 27899358
3. FRMD4A RNAi or inhibition of cytohesins strongly upregulated secretion of endogenous tau. These results suggest that FRMD4A, a genetic risk factor for late-onset Alzheimer's disease, regulates tau secretion by activating cytohesin-Arf6 signaling. PMID: 27044754
4. cytohesin inhibition has an antiproliferative effect in gefitinib-resistant lung cancer cells PMID: 22815959
5. findings suggest that cytohesin-1 is a key regulator of neutrophil adhesion to endothelial cells and to components of extracellular matrix, which may influence cell emigration through its dual opposing effect on beta2 and beta1 integrin activation PMID: 21511340
6. involvement of cytohesin-1 in the regulation of the functional responses of human PMNs, linked, in part at least, to the activation of Arf6. PMID: 20018626
7. Data show that CYTIP and cytoadhesin-1 are upregulated during dendritic cell maturation. PMID: 12606567
8. findings reveal that mycobacteria promote their uptake through a process of "inside-out" signaling involving CD14, TLR2, PI3K, and cytohesin-1. This converts low avidity CR3 into an active receptor leading to increased bacterial internalization PMID: 15778383
9. demonstrate an essential role of cytohesin-1/RhoA during ameboid migration in the presence of integrins PMID: 19346499
10. Phosphorylated cytohesin-1 is able to tightly associate with the actin cytoskeleton, and is required for maximal leukocyte function antigen-1-mediated adhesion of Jurkat cells to Icam-1. PMID: 11438522

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HGNC: 9501

OMIM: 182115

KEGG: hsa:9267

STRING: 9606.ENSP00000354398

UniGene: Hs.191215